Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3246
Abstract: Large granular lymphocyte (LGL) leukemia is a rare hematological disorder with expansion of the T‐cell or natural killer (NK) cell lineage. Signal transducer and activator of transcription 3 (STAT3) exhibits somatic activating mutations in 30%‐40%… read more here.
Keywords: stat3 mutations; granular lymphocyte; large granular; serum ... See more keywords
T-cell large granular lymphocyte leukemia in solid organ transplant recipients: case series and review of the literature
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DOI: 10.1007/s12185-019-02682-2
Abstract: T-cell large granular lymphocyte (T-LGL) leukemia is a rare clonal proliferation of cytotoxic lymphocytes rarely described in solid organ transplant (SOT). We reviewed records from 656 kidney transplant recipients in follow-up at our Center from… read more here.
Keywords: cell large; transplant; lgl leukemia; transplant recipients ... See more keywords
Choroidal Infiltration as First Clinical Manifestation of T-cell Large Granular Lymphocyte (T-LGL) Leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Ocular Immunology and Inflammation"
DOI: 10.1080/09273948.2019.1645186
Abstract: ABSTRACT Purpose: To report of a 55-year-old woman suffering from choroidal infiltrates as a first clinical manifestation of T-LGL leukemia. Methods: Retrospective case report. Results: A healthy woman presented with photophobia in both eyes since… read more here.
Keywords: choroidal; first clinical; clinical manifestation; lgl ... See more keywords
Abstract 2051: LSTRA cell line as a model for large granular lymphocytic leukemia in drug screening
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DOI: 10.1158/1538-7445.am2017-2051
Abstract: Large granular lymphocytic (LGL) leukemia is a rare form of leukemia that is caused by the increase in cytotoxic T-lymphocytes or natural killer (NK) cells. A subcategory of T-LGL leukemia that co-expresses T and NK… read more here.
Keywords: cell line; cell; bortezomib; resistance ... See more keywords
Frequent Somatic TET2 Mutations in Chronic NK-LGL Leukemia with Distinct Patterns of Cytopenias.
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DOI: 10.1182/blood.2020005831
Abstract: Chronic natural killer large granular lymphocyte (NK-LGL) leukemia, also referred to as chronic lymphoproliferative disorder of NK cells (CLPD-NK), is a rare disorder defined by prolonged expansion of clonal NK cells. Similar prevalence of STAT3… read more here.
Keywords: chronic lgl; tet2 mutations; mutations chronic; lgl leukemia ... See more keywords
Therapeutic Efficacy of Mcl-1 Antagonism in Large Granular Lymphocyte Leukemia
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DOI: 10.1182/blood.v130.suppl_1.1217.1217
Abstract: Introduction: Large granular lymphocyte (LGL) leukemia is a spectrum of rare clonal lymphoproliferative disorders, all of which involve expansion of large granular lymphocytes. Immunosuppressive regimens using methotrexate or cyclophosphamide are utilized as front-line treatments in… read more here.
Keywords: mcl; granular lymphocyte; large granular; lgl leukemia ... See more keywords
Intersection Between Large Granular Lymphocyte Leukemia and Rheumatoid Arthritis
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DOI: 10.3389/fonc.2022.869205
Abstract: Large granular lymphocyte (LGL) leukemia, a rare hematologic malignancy, has long been associated with rheumatoid arthritis (RA), and the diseases share numerous common features. This review aims to outline the parallels and comparisons between the… read more here.
Keywords: granular lymphocyte; leukemia; rheumatoid arthritis; lgl leukemia ... See more keywords
Clinical Study of the Relationship between Sjögren Syndrome and T-Cell Large Granular Lymphocytic Leukemia: Single-Center Experience
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DOI: 10.3390/ijms232113345
Abstract: The relationship between Sjögren syndrome (SS) and T-cell large granular lymphocytic (T-LGL) leukemia remains unclear. In this paper, we report for the first time a large case series of 21 patients with primary and secondary… read more here.
Keywords: syndrome cell; relationship gren; gren syndrome; cell large ... See more keywords