Theoretical structural characterization of lymphoguanylin: A potential candidate for the development of drugs to treat gastrointestinal disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2017.02.016
Abstract: Guanylin peptides (GPs) are small cysteine-rich peptide hormones involved in salt absorption, regulation of fluids and electrolyte homeostasis. This family presents four members: guanylin (GN), uroguanylin (UGN), lymphoguanylin (LGN) and renoguanylin (RGN). GPs have been… read more here.
Keywords: gastrointestinal disorders; theoretical structural; lgn; structural characterization ... See more keywords
Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions
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DOI: 10.1038/s41467-019-09999-w
Abstract: Cortical force generators connect epithelial polarity sites with astral microtubules, allowing dynein movement to orient the mitotic spindle as astral microtubules depolymerize. Complexes of the LGN and NuMA proteins, fundamental components of force generators, are… read more here.
Keywords: dynein dynactin; numa lgn; cortical force; lgn ... See more keywords