Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5+ cells during mouse inner ear development
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers of Medicine"
DOI: 10.1007/s11684-019-0703-y
Abstract: Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiation of hair cells (HCs) and supporting cells during mouse inner ear development; however, the relationship between the… read more here.
Keywords: lgr5 cells; cells mouse; wnt responsive; responsive lgr5 ... See more keywords
Establishing estrogen-responsive mouse mammary organoids from single Lgr5+ cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2016.08.001
Abstract: Recent evidence suggests that mammary cells expressing R-spondin receptor and Wnt pathway regulator Lgr5, regarded as a stem cell marker in multiple tissues, might represent mammary stem cells (MaSCs). Whether L gr5 marks a multipotent… read more here.
Keywords: lgr5 cells; mammary organoids; single lgr5; estrogen responsive ... See more keywords
LGR5 regulates osteogenic differentiation of human thoracic ligamentum flavum cells by Wnt signalling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17420
Abstract: Thoracic ossification of the ligamentum flavum (TOLF) is ectopic ossification of the spinal ligaments. Histologically, the development of TOLF can be described as the process of endochondral ossification. However, the underlying aetiology has not been… read more here.
Keywords: lgr5; osteogenic differentiation; wnt signalling; ligamentum flavum ... See more keywords
The proliferation and migration features of Lgr5+ stem cells and transit amplifying cells in the intestine are dynamically changed during the postnatal development
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731206
Abstract: Intestines continue to develop after birth, and the early neonatal period is a critical phase of gastrointestinal (GI) maturation. The intestinal epithelium takes a central role in mucosal physiological functions, and it experiences renewal ability… read more here.
Keywords: lgr5; physiology; migration; postnatal development ... See more keywords
Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Research"
DOI: 10.1155/2022/8938276
Abstract: Background Hair follicles are important accessory organs of the skin, and it is important for skin renewal and performs variety of important functions. Diabetes can cause several dermatoses; however, its effect on hair follicles is… read more here.
Keywords: lgr5; hair follicle; hair; mice ... See more keywords
Abstract 4085: Development and in vitro validation of an LGR-5 targeting CAR-T against colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4085
Abstract: Chimeric antigen receptor (CAR) T cells have demonstrated robust clinical efficacy against B-cell malignancies, and rapid translation to approval for use in man has inspired the search for CAR-T cells against solid tumours. Cancer stem… read more here.
Keywords: lgr5; cell; targeting car; car ... See more keywords
Abstract CT012: Clinical activity of MCLA-158 (petosemtamab), an IgG1 bispecific antibody targeting EGFR and LGR5, in advanced head and neck squamous cell cancer (HNSCC)
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct012
Abstract: EGFR is a known driver of cancer growth, and leucine-rich, repeat-containing, G-protein coupled receptor 5 (LGR5) is a transmembrane receptor expressed on cancer stem cells. Petosemtamab is a human, common light chain, IgG1 bispecific antibody… read more here.
Keywords: lgr5; igg1 bispecific; petosemtamab; activity ... See more keywords
Abstract CT156: MCLA-158 (petosemtamab), an IgG1 bispecific antibody targeting EGFR and LGR5, in advanced gastric/esophageal adenocarcinoma (GEA)
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct156
Abstract: The epidermal growth factor receptor (EGFR) is a known driver of cancer growth and the leucine-rich, repeat-containing, G-protein coupled receptor 5 (LGR5) is a transmembrane receptor expressed on cancer stem cells. Petosemtamab is a human,… read more here.
Keywords: lgr5; igg1 bispecific; petosemtamab; bispecific antibody ... See more keywords
Abstract A033: Depletion of Apc gene in Cdx2 gastro-intestinal cells facilitates metastasis of colorectal adenocarcinoma Lgr5 cells to distant organs
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/1538-7445.crc22-a033
Abstract: Background: Caudal-type homeobox 2 (CDX2) is a transcription factor expressed in the gastro-intestinal (GI) epithelial (IEC) and stromal cells. CDX2 along with APC can regulate Lgr5 intestinal stem cell (ISC) differentiation to control GI development… read more here.
Keywords: lgr5; metastasis; depletion; lgr5 cells ... See more keywords
Most colitis associated carcinomas lack expression of LGR5: a preliminary study with implications for unique pathways of carcinogenesis compared to sporadic colorectal carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "BMC Cancer"
DOI: 10.1186/s12885-021-07835-3
Abstract: Background Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a component of the Wnt receptor complex, is thought to lineage label gastric and intestinal stem cells. LGR5 expression is increased in colorectal carcinoma (CRC) compared to normal… read more here.
Keywords: colorectal carcinoma; cac; expression; colitis associated ... See more keywords
The biological functions of LGR5 in promoting non-small cell lung cancer progression
Sign Up to like & getrecommendations! Published in 2019 at "Translational Cancer Research"
DOI: 10.21037/tcr.2019.01.24
Abstract: Background The Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), which is used as a marker of adult stem cells and colorectal cancer stem cells (CSCs), is closely associated with the progression of non-small cell lung cancer… read more here.
Keywords: cancer; cell lung; small cell; non small ... See more keywords