Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5+ cells during mouse inner ear development
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers of Medicine"
DOI: 10.1007/s11684-019-0703-y
Abstract: Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiation of hair cells (HCs) and supporting cells during mouse inner ear development; however, the relationship between the… read more here.
Keywords: lgr5 cells; cells mouse; wnt responsive; responsive lgr5 ... See more keywords
Establishing estrogen-responsive mouse mammary organoids from single Lgr5+ cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2016.08.001
Abstract: Recent evidence suggests that mammary cells expressing R-spondin receptor and Wnt pathway regulator Lgr5, regarded as a stem cell marker in multiple tissues, might represent mammary stem cells (MaSCs). Whether L gr5 marks a multipotent… read more here.
Keywords: lgr5 cells; mammary organoids; single lgr5; estrogen responsive ... See more keywords
Abstract A033: Depletion of Apc gene in Cdx2 gastro-intestinal cells facilitates metastasis of colorectal adenocarcinoma Lgr5 cells to distant organs
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/1538-7445.crc22-a033
Abstract: Background: Caudal-type homeobox 2 (CDX2) is a transcription factor expressed in the gastro-intestinal (GI) epithelial (IEC) and stromal cells. CDX2 along with APC can regulate Lgr5 intestinal stem cell (ISC) differentiation to control GI development… read more here.
Keywords: lgr5; metastasis; depletion; lgr5 cells ... See more keywords
Abstract A05: Deep immunofluorescence imaging of solvent-cleared mouse mammary glands
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.advbc17-a05
Abstract: We seek to trace the progression of epithelial lesions originating from Lgr5+ cells in mouse mammary glands using the 3DISCO protocol for solvent-cleared tissue. Lineage tracing is increasingly being used to probe different cell types… read more here.
Keywords: lgr5 cells; mammary glands; solvent cleared; mouse mammary ... See more keywords
Lgr5+ cells are required and dynamically participate in olfactory epithelium regeneration: a revisiting shows Lgr5 expression in multiple cell lineages
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.60636
Abstract: Olfactory sensory neurons (OSNs) located in the olfactory epithelium (OE) detect thousands of volatile environmental odors to form the sense of smell. OSNs are generated from basal cells, which show the characteristics of progenitor/stem cells.… read more here.
Keywords: regeneration; role lgr5; homeostasis; lgr5 cells ... See more keywords