Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.11.001
Abstract: Lgr5+ adult intestinal stem cells are highly proliferative throughout life. Single Lgr5+ stem cells can be cultured into three-dimensional organoids containing all intestinal epithelial cell types at near-normal ratios. Conditions to generate the main cell… read more here.
Keywords: hormone producing; cell; lgr5 stem; stem ... See more keywords
Identification of Quiescent LGR5+ Stem Cells in the Human Colon.
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DOI: 10.1053/j.gastro.2022.07.081
Abstract: BACKGROUND & AIMS In the mouse intestinal epithelium, Lgr5+ stem cells are vulnerable to injury owing to their predominantly cycling nature, and their progenies de-differentiate to replenish the stem cell pool. However, how human colonic… read more here.
Keywords: stem; lgr5 stem; stem cells; human colon ... See more keywords
The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology
Sign Up to like & getrecommendations! Published in 2017 at "Biological Research"
DOI: 10.1186/s40659-017-0151-6
Abstract: BackgroundThe WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase enzymes tankyrase1 and 2. LGR5 is a known WNT… read more here.
Keywords: cell; tankyrase inhibitor; lgr5 stem; stem ... See more keywords