Novel disaccharide inhibitors for the bacterial galactosyltransferase LgtC: Design, synthesis via Heyns rearrangement, and biochemical evaluation.
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DOI: 10.1016/j.carres.2020.108017
Abstract: Bacterial glycosyltransferases are potential targets for the development of novel antibiotics and anti-virulence agents. We report a novel inhibitor design for the retaining α-1,4-galactosyltransferase LgtC from Neisseria meningitidis. Our design is based on the installation… read more here.
Keywords: galactosyltransferase lgtc; heyns rearrangement; synthesis; lgtc ... See more keywords