Actions of Neuropeptide Y on Synaptic Transmission in the Lateral Habenula
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.04.053
Abstract: Neuropeptide Y is a peptide neuromodulator with protective roles including anxiolytic and antidepressant-like effects in animal models of depression and post-traumatic stress disorder. The lateral habenula (LHb) is a brain region that encodes aversive information… read more here.
Keywords: lhb neurons; transmission; lhb; synaptic transmission ... See more keywords
The Lateral Habenula and Adaptive Behaviors
Sign Up to like & getrecommendations! Published in 2017 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2017.06.001
Abstract: The evolutionarily conserved lateral habenula (LHb) enables dynamic responses to continually changing contexts and environmental conditions. A model is proposed to account for greater mnemonic and contextual control over LHb-mediated response flexibility as vertebrate brains… read more here.
Keywords: response; lhb; habenula; habenula adaptive ... See more keywords
Lateral Habenula Involvement in Impulsive Cocaine Seeking
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2016.286
Abstract: The lateral habenula (LHb) is a brain structure receiving inputs from limbic forebrain areas and innervating major midbrain monoaminergic nuclei. Evidence indicates LHb involvement in sleep control, reward-based decision making, avoidance of punishment, and responses… read more here.
Keywords: lhb; cocaine seeking; drug; cocaine ... See more keywords
A novel role for the lateral habenula in fear learning
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-022-01294-5
Abstract: Fear is an extreme form of aversion that underlies pathological conditions such as panic or phobias. Fear conditioning (FC) is the best-understood model of fear learning. In FC the context and a cue are independently… read more here.
Keywords: lateral habenula; role; fear learning; lhb ... See more keywords
Downregulation of M-channels in lateral habenula mediates hyperalgesia during alcohol withdrawal in rats
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-38393-7
Abstract: Hyperalgesia often occurs in alcoholics, especially during abstinence, yet the underlying mechanisms remain elusive. The lateral habenula (LHb) has been implicated in the pathophysiology of pain and alcohol use disorders. Suppression of m-type potassium channels… read more here.
Keywords: lhb; hyperalgesia alcohol; withdrawal; alcohol ... See more keywords
Cometary impact rates on the Moon and planets during the late heavy bombardment
Sign Up to like & getrecommendations! Published in 2017 at "Astronomy and Astrophysics"
DOI: 10.1051/0004-6361/201629376
Abstract: Context. The Nice model predicts that the trans-planetary planetesimal disk made a large or even dominant contribution to the cratering in the inner solar system during the late heavy bombardment (LHB). In the presence of… read more here.
Keywords: late heavy; disk; heavy bombardment; lhb ... See more keywords
Pharmacological evaluation of lateral habenula and rostromedial tegmental nucleus in the expression of ethanol-induced place preference
Sign Up to like & getrecommendations! Published in 2023 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000728
Abstract: Although ethanol administration produces a range of physiological effects, the rewarding aspect associated with its consumption is a major contributory factor to its abuse liability. Recently, lateral habenula (LHb) has been shown to be engaged… read more here.
Keywords: lateral habenula; administration; ethanol; cpp ... See more keywords
Habenular connections with the dopaminergic and serotonergic system and their role in stress‐related psychiatric disorders
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14647
Abstract: The habenula (Hb) is a phylogenetically old epithalamic structure differentiated into two nuclear complexes, the medial (MHb) and lateral habenula (LHb). After decades of search for a great unifying function, interest in the Hb resurged… read more here.
Keywords: connections dopaminergic; mhb; lhb; role ... See more keywords
The Role of the Lateral Habenula in Suicide: A Call for Further Exploration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.812952
Abstract: Despite decades of significant effort in research, policy, and prevention, suicide rates have continued to rise to the current peak of 14.6 per 100,000 deaths. This has resulted in a concerted effort to identify biomarkers… read more here.
Keywords: lateral habenula; suicide; role; suicidal behavior ... See more keywords
Safety and precision of frontal trajectory of lateral habenula deep brain stimulation surgery in treatment-resistant depression
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2023.1113545
Abstract: Introduction The lateral habenula (LHb) is a promising deep brain stimulation (DBS) target for treatment-resistant depression (TRD). However, the optimal surgical trajectory and its safety of LHb DBS are lacking. Methods We reported surgical trajectories… read more here.
Keywords: lateral habenula; dbs; safety; surgery ... See more keywords
Output-Specific Adaptation of Habenula-Midbrain Excitatory Synapses During Cocaine Withdrawal
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2021.643138
Abstract: Projections from the lateral habenula (LHb) control ventral tegmental area (VTA) neuronal populations’ activity and both nuclei shape the pathological behaviors emerging during cocaine withdrawal. However, it is unknown whether cocaine withdrawal modulates LHb neurotransmission… read more here.
Keywords: withdrawal; onto vta; lhb; cocaine withdrawal ... See more keywords