A heparin conjugate, LHbisD4, inhibits lymphangiogenesis and attenuates lymph node metastasis by blocking VEGF-C signaling pathway.
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DOI: 10.1016/j.biomaterials.2017.05.026
Abstract: Clinical studies have found that the incidence of cancer metastasis through the lymphatic vessels are 3-5 times higher than that through the blood vessels. These findings suggest the potency of anti-lymphangiogenic therapy in reducing the… read more here.
Keywords: lhbisd4; metastasis blocking; metastasis; signaling pathway ... See more keywords