Selection of DNA-encoded Libraries to Protein Targets Within and On Living Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b08085
Abstract: We report the selection of DNA-encoded small molecule libraries against protein targets within the cytosol and on the surface of live cells. The approach relies on generation of a covalent linkage of the DNA to… read more here.
Keywords: dna; targets within; dna encoded; protein targets ... See more keywords
Critical Features of Fragment Libraries for Protein Structure Prediction
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DOI: 10.1371/journal.pone.0170131
Abstract: The use of fragment libraries is a popular approach among protein structure prediction methods and has proven to substantially improve the quality of predicted structures. However, some vital aspects of a fragment library that influence… read more here.
Keywords: libraries protein; protein structure; fragment libraries; structure ... See more keywords