Copper(I/II)-Promoted Diverse Imidazo[1,2-α]pyridine Synthesis on Solid-Phase Bound DNA Oligonucleotides for Encoded Library Design.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01834
Abstract: DNA-encoded libraries designed around heterocyclic scaffolds have proven highly productive in target-based screening. Here, we show the synthesis of imidazopyridines on a controlled pore glass-coupled DNA oligonucleotide for solid phase-initiated encoded library synthesis. The target… read more here.
Keywords: dna; library design; encoded library; solid phase ... See more keywords
Engaging Students in Academic Library Design: Emergent Practices in Co-Design
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DOI: 10.1080/13614533.2020.1761409
Abstract: Abstract This article explores academic libraries that have gone beyond using the traditional survey or focus group methods of soliciting student input, specific to library design projects. The goal for each library was to engage… read more here.
Keywords: library design; input; academic library; emergent practices ... See more keywords
Selection of Functional Intracellular Nanobodies
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DOI: 10.1177/2472555219853235
Abstract: Camelid-derived nanobodies are versatile tools for research, diagnostics, and therapeutics. Certain nanobodies can function as intrabodies and bind antigens within the eukaryotic cytosol. This capability is valuable for the development of intracellular probes and targeted… read more here.
Keywords: library design; selection functional; functional intracellular; intracellular nanobodies ... See more keywords
Key Aspects of Nucleic Acid Library Design for in Vitro Selection
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DOI: 10.3390/ijms19020470
Abstract: Nucleic acid aptamers capable of selectively recognizing their target molecules have nowadays been established as powerful and tunable tools for biospecific applications, be it therapeutics, drug delivery systems or biosensors. It is now generally acknowledged… read more here.
Keywords: library design; vitro selection; selection; nucleic acid ... See more keywords