Expanding the Medicinal Chemist Toolbox: Comparing Seven C(sp2)–C(sp3) Cross-Coupling Methods by Library Synthesis
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DOI: 10.1021/acsmedchemlett.0c00093
Abstract: Despite recent advances in the field of C(sp2)–C(sp3) cross-couplings and the accompanying increase in publications, it can be hard to determine which method is appropriate for a given reaction when using the highly functionalized intermediates… read more here.
Keywords: library synthesis; sp2 sp3; chemistry; sp3 cross ... See more keywords
Automated stopped-flow library synthesis for rapid optimisation and machine learning directed experimentation
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc03016k
Abstract: For the discovery of new candidate molecules in the pharmaceutical industry, library synthesis is a critical step, in which library size, diversity, and time to synthesise are fundamental. In this work we propose stopped-flow synthesis… read more here.
Keywords: reaction; machine learning; synthesis; stopped flow ... See more keywords