Employing LiCl salt gradient in the wild-type α-hemolysin nanopore to slow down DNA translocation and detect methylated cytosine.
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DOI: 10.1039/c9nr00502a
Abstract: In this research, we demonstrate a label-free detection, biological nanopore-based method to distinguish methylated cytosine (mC) from naked cytosine (C) in sample mixtures containing both C and mC at a prolonged translocation duration. Using a… read more here.
Keywords: licl salt; dna; capture rate; methylated cytosine ... See more keywords