Licochalcone A attenuates acne symptoms mediated by suppression of NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2018 at "Phytotherapy Research"
DOI: 10.1002/ptr.6195
Abstract: Activation of the NACHT, LRR and PYD domains‐containing protein 3 (NLRP3) inflammasome by Propionibacterium acnes (P. acnes) is critical for inducing inflammation and aggravating the development of acne lesions. We searched for available small‐molecule inhibitors… read more here.
Keywords: inflammasome licochalcone; licochalcone; nlrp3 inflammasome; acnes induced ... See more keywords
Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-κB and Ras/Raf/MEK pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.113989
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Glycyrrhiza glabra L., a traditional medicinal, has a history of thousands of years. It is widely used in clinic and has been listed in Chinese Pharmacopoeia. Licochalcone A is a phenolic chalcone compound… read more here.
Keywords: apoptosis; licochalcone; proliferation; programmed cell ... See more keywords
Licochalcone B, a chalcone derivative from Glycyrrhiza inflata, as a multifunctional agent for the treatment of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1496429
Abstract: Abstract Licochalcone B (LCB), an extract from the root of Glycyrrhiza inflate, has the same caffeic acid scaffold as curcumin (Cur), which is known as an anti-Alzheimer’s disease (AD) agent. However, there is no relevant… read more here.
Keywords: agent; licochalcone; alzheimer disease; multifunctional agent ... See more keywords
Licochalcone A inhibits EGFR signalling and translationally suppresses survivin expression in human cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16135
Abstract: Dysfunction of epidermal growth factor receptor (EGFR) signalling plays a critical role in the oncogenesis of non–small‐cell lung cancer (NSCLC). Here, we reported the natural product, licochalcone A, exhibited a profound anti‐tumour efficacy through directly… read more here.
Keywords: licochalcone; egfr signalling; nsclc cells; cancer ... See more keywords
Licochalcone A Promotes the Ubiquitination of c-Met to Abrogate Gefitinib Resistance
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DOI: 10.1155/2022/5687832
Abstract: Met proto-oncogene (MET) amplification and tyrosine-protein kinase Met (c-Met) overexpression confer gefitinib resistance in non-small cell lung cancer (NSCLC). The natural product Licochalcone A (Lico A) exhibits a broad range of inhibitory effects against various… read more here.
Keywords: resistance nsclc; licochalcone; resistance; gefitinib resistance ... See more keywords
Biocompatible combinations of nisin and licorice polyphenols exert synergistic bactericidal effects against Enterococcus faecalis and inhibit NF-κB activation in monocytes
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DOI: 10.1186/s13568-020-01056-w
Abstract: Enterococcus faecalis is one of the bacterial species most frequently isolated from persistent endodontic and apical periodontal infections. The aim of the present study was to evaluate the synergistic antibacterial effects of nisin and selected… read more here.
Keywords: glabridin licoricidin; nisin licorice; licorice polyphenols; licochalcone ... See more keywords
Biological Effect of Licochalcone C on the Regulation of PI3K/Akt/eNOS and NF-κB/iNOS/NO Signaling Pathways in H9c2 Cells in Response to LPS Stimulation
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DOI: 10.3390/ijms18040690
Abstract: Polyphenols compounds are a group molecules present in many plants. They have antioxidant properties and can also be helpful in the management of sepsis. Licochalcone C (LicoC), a constituent of Glycyrrhiza glabra, has various biological… read more here.
Keywords: pi3k; h9c2 cells; response; licochalcone ... See more keywords
Antitumor effects and the underlying mechanism of licochalcone A combined with 5-fluorouracil in gastric cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2017.5614
Abstract: Licochalcone A (LCA) is a flavonoid extracted from licorice root that has antiparasitic, antibacterial and antitumor properties. Previous studies have revealed that LCA may be a novel treatment for gastric cancer. The present study further… read more here.
Keywords: gastric cancer; licochalcone; antitumor effects; cancer cells ... See more keywords
Licochalcone H induces the apoptosis of human oral squamous cell carcinoma cells via regulation of matrin 3
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DOI: 10.3892/or.2018.6784
Abstract: Licochalcone H (LCH) is a chemical compound that is a positional isomer of licochalcone C (LCC), a chalconoid isolated from the root of Glycyrrhiza inflata, which has various pharmacological properties including anti-inflammatory, antioxidant, antitumor, and… read more here.
Keywords: regulation matrin; licochalcone; oral squamous; squamous cell ... See more keywords