Pharmacokinetics of Lidocaine and Its Metabolites Following Vaginal Administration of Lidocaine Gel to Healthy Female Subjects
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DOI: 10.1002/cpdd.286
Abstract: Lidocaine vaginal bioadhesive gel is being developed as a local anesthetic for use in minimally invasive outpatient gynecological procedures and was investigated in single‐dose and multiple‐dose studies in healthy young adult women. Lidocaine doses of… read more here.
Keywords: administration; lidocaine metabolites; pharmacokinetics lidocaine; lidocaine ... See more keywords
Lidocaine inhibits melanoma cell proliferation by regulating ERK phosphorylation
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DOI: 10.1002/jcb.27927
Abstract: The melanoma is responsible for the majority of all skin cancer–related deaths worldwide. Evidence suggests that local anesthetics provide some benefit in the treatment of cancer via inhibition of cellular proliferation, invasion and migration. However,… read more here.
Keywords: melanoma cell; erk phosphorylation; cell proliferation; proliferation ... See more keywords
Population pharmacokinetic model for tumescent lidocaine in women undergoing breast cancer surgery
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DOI: 10.1007/s00228-018-2503-8
Abstract: PurposeTumescent lidocaine anesthesia (TLA) is an opportunity to perform mastectomy for breast cancer without general anesthesia in elderly women. Few reports are available on the pharmacokinetics of lidocaine in a context of TLA during a… read more here.
Keywords: women undergoing; tumescent lidocaine; lidocaine; breast cancer ... See more keywords
Clinically relevant concentrations of lidocaine inhibit tumor angiogenesis through suppressing VEGF/VEGFR2 signaling
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DOI: 10.1007/s00280-019-03815-4
Abstract: BackgroundAngiogenesis, the formation of blood vessel, is required for invasive tumor growth and metastasis. In this study, the effects of lidocaine, an amide-link local anesthetic, on angiogenesis and tumor growth were investigated.MethodsIn vitro angiogenesis assays… read more here.
Keywords: angiogenesis; cell; lidocaine; growth ... See more keywords
The analgesic efficacy and duration of lidocaine on vascular pain induced by hypertonic saline infusion: a double-blinded, randomized control trial
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DOI: 10.1007/s00540-019-02628-2
Abstract: PurposeTo determine the analgesic efficacy and analgesic duration of lidocaine 20 mg and 40 mg on eliminating the vascular pain associated with hypertonic saline infusion.MethodPatients who complained pain during infusion of hypertonic saline were randomized into three… read more here.
Keywords: duration; group; lidocaine; hypertonic saline ... See more keywords
Bupivacaine vs. lidocaine: a comparison of local anesthetic efficacy in impacted third molar surgery
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DOI: 10.1007/s00784-020-03224-5
Abstract: Objectives The aim of this study was to compare the anesthetic efficacy, the duration of anesthesia, and the postoperative analgesia of lidocaine and bupivacaine and to determine any difference in hemodynamic parameters in patients who… read more here.
Keywords: duration; third molar; bupivacaine; anesthetic efficacy ... See more keywords
Continuous intravenous lidocaine infusion for postoperative pain and recovery in adults
Sign Up to like & getrecommendations! Published in 2018 at "Techniques in Coloproctology"
DOI: 10.1007/s10151-018-1890-2
Abstract: Selection criteria We included randomized controlled trials comparing the effect of continuous perioperative IV lidocaine infusion either with placebo, or no treatment, or with thoracic epidural analgesia (TEA) in adults undergoing elective or urgent surgery… read more here.
Keywords: lidocaine infusion; infusion postoperative; intravenous lidocaine; lidocaine ... See more keywords
Drug-coated microneedles for rapid and painless local anesthesia
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DOI: 10.1007/s10544-016-0144-1
Abstract: This study showed that drug-coated PLLA (Poly (L-lactide)) microneedle arrays can induce rapid and painless local anesthesia. Microneedle arrays were fabricated using a micro-molding technique, and the needle tips were coated with 290.6 ± 45.9 μg of lidocaine,… read more here.
Keywords: microneedle arrays; drug coated; lidocaine; local anesthesia ... See more keywords
Lidocaine Attenuates Cognitive Impairment After Isoflurane Anesthesia by Reducing Mitochondrial Damage
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DOI: 10.1007/s11064-019-02799-0
Abstract: Mitochondrial dysfunction has been proposed to be one of the earliest triggering events in isoflurane-induced neuronal damage. Lidocaine has been demonstrated to attenuate the impairment of cognition in aged rats induced by isoflurane in our… read more here.
Keywords: mitochondrial damage; cognitive impairment; lidocaine; damage ... See more keywords
Association between intraoperative intravenous lidocaine infusion and survival in patients undergoing pancreatectomy for pancreatic cancer: a retrospective study.
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DOI: 10.1016/j.bja.2020.03.034
Abstract: BACKGROUND Intravenous lidocaine has been shown to reduce opioid consumption and is associated with favourable outcomes after surgery. In this study, we explored whether intraoperative lidocaine reduces intraoperative opioid use and length of stay (LOS)… read more here.
Keywords: lidocaine infusion; study; intravenous lidocaine; lidocaine ... See more keywords
Neutrophil extracellular trapping and angiogenesis biomarkers after intravenous or inhalation anaesthesia with or without intravenous lidocaine for breast cancer surgery: a prospective, randomised trial.
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DOI: 10.1016/j.bja.2020.05.003
Abstract: BACKGROUND Experimental and, retrospective, clinical data indicate that anaesthetic technique might influence the risk of metastasis after cancer surgery. Neutrophil extracellular trapping (NETosis) is an immunological mechanism strongly linked with increased metastatic risk. Similarly, vascular… read more here.
Keywords: cancer surgery; breast; anaesthetic technique; lidocaine ... See more keywords