Lidocaine attenuates lipopolysaccharide-induced inflammatory responses and protects against endotoxemia in mice by suppressing HIF1α-induced glycolysis.
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DOI: 10.1016/j.intimp.2019.106150
Abstract: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infections. Previous studies have indicated that lidocaine, an amide local anesthetic, has anti-inflammatory properties; however, the underlying mechanism remains unclear.… read more here.
Keywords: glycolysis; attenuates lipopolysaccharide; inflammatory; hif1 induced ... See more keywords