Altered expression of leukemia inhibitory factor (LIF), LIFR, gp130, and IL11 in the embryo implantation site of rat model with prenatal androgen-induced polycystic ovary syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.03.053
Abstract: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that represents infertility in many reproductive-age women. Reduced implantation of blastocyst was proposed as an etiology for infertility in this syndrome. In this regard, many candidate… read more here.
Keywords: lifr; lif lifr; expression; lif ... See more keywords
The role of adiposity in enhancing LIF/LIFR signaling pathway in endometrial cancer
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic Oncology"
DOI: 10.1016/s0090-8258(21)01228-2
Abstract: Objectives: The incidence of endometrial cancer (EC) is estimated to increase by 1-2% annually. More than half of all EC diagnoses are currently attributable to obesity, which is an independent risk factor for this cancer.… read more here.
Keywords: lifr; lifr signaling; adiposity; tissue ... See more keywords
EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-18-1258
Abstract: Leukemia inhibitory factor receptor (LIFR) and its ligand LIF play a critical role in cancer progression, metastasis, stem cell maintenance, and therapy resistance. Here, we describe a rationally designed first-in-class inhibitor of LIFR, EC359, which… read more here.
Keywords: negative breast; lifr; cancer; lif lifr ... See more keywords
Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1140730
Abstract: Introduction The leukemia inhibitory factor (LIF), is a cytokine belonging to IL-6 family, whose overexpression correlate with poor prognosis in cancer patients, including pancreatic ductal adenocarcinoma (PDAC). LIF signaling is mediate by its binding to… read more here.
Keywords: inhibitory factor; lif lifr; bar502; leukemia inhibitory ... See more keywords
Inhibition of LIFR Blocks Adiposity-Driven Endometrioid Endometrial Cancer Growth
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14215400
Abstract: Simple Summary In this study, we utilized global RNA-seq to elucidate the molecular mechanisms by which obese conditions promote progression of endometrioid endometrial cancer (EEC). Our results suggest that obese conditions upregulate LIF/LIFR signaling, and… read more here.
Keywords: endometrial cancer; progression; lif lifr; eec ... See more keywords