Early-life starvation alters lipid metabolism in adults to cause developmental pathology in Caenorhabditis elegans.
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DOI: 10.1093/genetics/iyac172
Abstract: Early-life malnutrition increases adult disease risk in humans, but the causal changes in gene regulation, signaling, and metabolism are unclear. In the roundworm Caenorhabditis elegans, early-life starvation causes well-fed larvae to develop germline tumors and… read more here.
Keywords: life starvation; early life; development; pathology ... See more keywords
Insulin/IGF-dependent Wnt signaling promotes formation of germline tumors and other developmental abnormalities following early-life starvation in Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac173
Abstract: The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that early-life stressors can predispose people to disease later in life. In the roundworm Caenorhabditis elegans, prolonged early-life starvation causes germline tumors, uterine masses and… read more here.
Keywords: life starvation; early life; starvation; wnt signaling ... See more keywords