Reduced Oligodendrocyte Precursor Cell Impairs Astrocytic Development in Early Life Stress
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DOI: 10.1002/advs.202101181
Abstract: Abstract Astrocyte maldevelopment is implicated in various neuropsychiatric diseases associated with early life stress. However, the underlying astrocytopathy mechanism, which can result in the psychiatric symptoms, remains unclear. In this study, it is shown that… read more here.
Keywords: life stress; early life; astrocytic development;
Alcohol, psychomotor-stimulants and behaviour: methodological considerations in preclinical models of early-life stress
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4852-5
Abstract: BackgroundIn order to assess the risk associated with early-life stress, there has been an increase in the amount of preclinical studies investigating early-life stress. There are many challenges associated with investigating early-life stress in animal… read more here.
Keywords: methodological considerations; life stress; early life; alcohol psychomotor ... See more keywords
Life stress, uncertainty stress and self-reported illness: a representative nationwide study of Chinese students
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DOI: 10.1007/s10389-017-0837-9
Abstract: PurposeTo examine the association between life stress, uncertainty stress and self-reported illness among Chinese college students.MethodsParticipants were 11,942 students who were identified through a multistage survey sampling process that included 50 universities. Stress and illness… read more here.
Keywords: life stress; stress; stress uncertainty; uncertainty stress ... See more keywords
Episodic Life Stress and the Development of Overgeneral Autobiographical Memory to Positive Cues in Youth
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Abnormal Child Psychology"
DOI: 10.1007/s10802-018-0409-7
Abstract: Overgeneral autobiographical memory (OGM) has been established as a risk factor for depression in both youth and adults, but questions remain as to how OGM develops. Although theorists have proposed that the experience of stressful… read more here.
Keywords: life stress; autobiographical memory; life; development ... See more keywords
Early life stress in mice is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.05.024
Abstract: Neonatal period is characterized by an immature intestinal barrier. Scattered evidence suggests that early life stressful events induce long lasting alterations of intestinal homeostasis mimicking Irritable Bowel Syndrome (IBS). Those observations highlighting defect of intestinal… read more here.
Keywords: colitis; life stress; early life; mice ... See more keywords
Genome-wide Signatures of Early-Life Stress: Influence of Sex
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DOI: 10.1016/j.biopsych.2020.12.010
Abstract: Both history of early-life stress (ELS) and female sex are associated with increased risk for depression. The complexity of how ELS interacts with brain development and sex to impart risk for multifaceted neuropsychiatric disorders is… read more here.
Keywords: genome wide; life stress; influence sex; early life ... See more keywords
Early-life stress increases granule cell density in the cerebellum of male rats
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2019.146358
Abstract: In rodents, daily maternal separation for 180 minutes (MS180) during the first weeks of life affects hippocampal granule cell neurogenesis. Development of the cerebellum granule cell layer also occurs during the first weeks of life.… read more here.
Keywords: granule cell; life stress; early life; ms180 ... See more keywords
Early Life Stress Drives Sex-Selective Impairment in Reversal Learning by Affecting Parvalbumin Interneurons in Orbitofrontal Cortex of Mice
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DOI: 10.1016/j.celrep.2018.11.010
Abstract: SUMMARY Poverty, displacement, and parental stress represent potent sources of early life stress (ELS). Stress disproportionately affects females, who are at increased risk for stress-related pathologies associated with cognitive impairment. Mechanisms underlying stress-associated cognitive impairment… read more here.
Keywords: life stress; early life; stress; impairment ... See more keywords
Dysregulation of the mesoprefrontal dopamine circuit mediates an early-life stress-induced synaptic imbalance in the prefrontal cortex.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109074
Abstract: Stress adversely affects an array of cognitive functions. Although stress-related disorders are often addressed in adulthood, far less is known about how early-life stress (ELS) affects the developing brain in early postnatal periods. Here we… read more here.
Keywords: life stress; early life; stress; dysregulation mesoprefrontal ... See more keywords
Interactions between early life stress and metabolic stress in programming of mental and metabolic health
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Behavioral Sciences"
DOI: 10.1016/j.cobeha.2016.12.009
Abstract: The long-term consequences of psychosocial and socioeconomic challenges are hardly distinguishable from those of inappropriate nutrition, suggesting the existence of common physiological pathways funnelling the effects of early adversity. Obesity and mood disorders are highly… read more here.
Keywords: life stress; early life; interactions early; stress ... See more keywords
Design, rationale and feasibility of a multidimensional experimental protocol to study early life stress
Sign Up to like & getrecommendations! Published in 2017 at "Contemporary Clinical Trials Communications"
DOI: 10.1016/j.conctc.2017.05.003
Abstract: There is a rapidly accumulating body of evidence regarding the influential role of early life stress (ELS) upon medical and psychiatric conditions. While self-report instruments, with their intrinsic limitations of recall, remain the primary means… read more here.
Keywords: life stress; early life; protocol; stress ... See more keywords