Neoagarotetraose extends the lifespan of Caenorhabditis elegans through AMPK mediated signaling pathways and activation of autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2020.104341
Abstract: Abstract Neoagarotetraose (NAT) has been reported to ameliorate aging-associated diseases. The present study found that NAT extended the lifespan of Caenorhabditis (C.) elegans up to 21.9% and improved resistance to stresses of heat and oxidation.… read more here.
Keywords: elegans ampk; extends lifespan; caenorhabditis elegans; neoagarotetraose extends ... See more keywords
Autophagy plays a role in the prolongation of the lifespan of Caenorhabditis elegans by astaxanthin.
Sign Up to like & getrecommendations! Published in 2020 at "Rejuvenation research"
DOI: 10.1089/rej.2020.2355
Abstract: Astaxanthin, a xanthophyll belonging to the family of carotenoids, is a potent antioxidant. The effect of astaxanthin on longevity and its physiological and molecular mechanism are still unclear. In this study, we proved that astaxanthin… read more here.
Keywords: role prolongation; caenorhabditis elegans; lifespan caenorhabditis; signal pathway ... See more keywords
Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the Insulin/IGF-1 Signalling Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/4740739
Abstract: Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against Aβ-induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis… read more here.
Keywords: elegans via; medicine; extends lifespan; via insulin ... See more keywords
Quetiapine Shortens the Lifespan of Caenorhabditis elegans through DOP-2, DAF-2 and RSKS-1
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232112927
Abstract: Recent studies implicate a key role of dopamine signaling in lifespan regulation. Our previous study found that quetiapine, an atypical antipsychotic drug that has antagonistic activity on dopamine D2-like receptors (D2Rs), shortened the lifespan of… read more here.
Keywords: effect; caenorhabditis elegans; lifespan caenorhabditis; quetiapine shortens ... See more keywords
Sonneradon A Extends Lifespan of Caenorhabditis elegans by Modulating Mitochondrial and IIS Signaling Pathways.
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DOI: 10.3390/md20010059
Abstract: Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Sonneradon A (SDA), a new compound first extracted from the edible fruits of mangrove Sonneratia apetala, showed remarkable… read more here.
Keywords: sonneradon extends; sda; caenorhabditis elegans; lifespan caenorhabditis ... See more keywords
Curcumin Acetylsalicylate Extends the Lifespan of Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26216609
Abstract: Aspirin and curcumin have been reported to be beneficial to anti-aging in a variety of biological models. Here, we synthesized a novel compound, curcumin acetylsalicylate (CA), by combining aspirin and curcumin. We characterized how CA… read more here.
Keywords: curcumin acetylsalicylate; caenorhabditis elegans; lifespan caenorhabditis; acetylsalicylate extends ... See more keywords