Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21743-x
Abstract: Protein homeostasis is modulated by stress response pathways and its deficiency is a hallmark of aging. The integrated stress response (ISR) is a conserved stress-signaling pathway that tunes mRNA translation via phosphorylation of the translation… read more here.
Keywords: lifespan extension; translation; stress response; inhibition ... See more keywords
Preservation of mitochondrial membrane potential is necessary for lifespan extension from dietary restriction
Sign Up to like & getrecommendations! Published in 2022 at "GeroScience"
DOI: 10.1101/2022.12.27.522028
Abstract: Dietary restriction (DR) increases lifespan in many organisms, but its underlying mechanisms are not fully understood. Mitochondria play a central role in metabolic regulation and are known to undergo changes in structure and function in… read more here.
Keywords: membrane potential; mitochondrial membrane; lifespan extension; dietary restriction ... See more keywords
Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects
Sign Up to like & getrecommendations! Published in 2020 at "Aging Cell"
DOI: 10.1111/acel.13269
Abstract: To see if variations in timing of rapamycin (Rapa), administered to middle aged mice starting at 20 months, would lead to different survival outcomes, we compared three dosing regimens. Initiation of Rapa at 42 ppm… read more here.
Keywords: rapa; lifespan extension; extension late; mediated mouse ... See more keywords
Cap‐independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α‐estradiol
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DOI: 10.1111/acel.13345
Abstract: We hypothesized that rapamycin (Rapa), acarbose (ACA), which both increase mouse lifespan, and 17α‐estradiol, which increases lifespan in males (17aE2) all share common intracellular signaling pathways with long‐lived Snell dwarf, PAPPA‐KO, and Ghr−/− mice. The… read more here.
Keywords: lifespan extension; translation; cap independent; independent translation ... See more keywords
The integrated stress response in budding yeast lifespan extension
Sign Up to like & getrecommendations! Published in 2017 at "Microbial Cell"
DOI: 10.15698/mic2017.11.597
Abstract: Aging is a complex, multi-factorial biological process shared by all living organisms. It is manifested by a gradual accumulation of molecular alterations that lead to the decline of normal physiological functions in a time-dependent fashion.… read more here.
Keywords: lifespan extension; budding yeast; integrated stress; stress response ... See more keywords
Synthesis and Evaluation of the Lifespan-Extension Properties of Oleracones D–F, Antioxidative Flavonoids from Portulaca oleracea L.
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DOI: 10.3390/app9194014
Abstract: Plant-derived antioxidants have been widely used as supplementary health foods, as well as having been regarded as drug candidates for aging and aging-associated diseases. Oleracones, a novel series of flavonoids isolated from Portulaca oleracea L.,… read more here.
Keywords: extension properties; lifespan extension; portulaca oleracea; synthesis evaluation ... See more keywords
Ferulic Acid Supplementation Increases Lifespan and Stress Resistance via Insulin/IGF-1 Signaling Pathway in C. elegans
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22084279
Abstract: Ferulic acid (FA) is a naturally-occurring well-known potent antioxidant and free radical scavenger. FA supplementation is an effective strategy to delay aging, but the underlying mechanism remains unknown. In the present study, we examined the… read more here.
Keywords: lifespan extension; supplementation; igf signaling; insulin igf ... See more keywords