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Published in 2019 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2019.03.005
Abstract: Although survival has been the focus of aging research for many years, the field is rapidly evolving towards incorporating healthspan and health indices in studies that explore aging-related outcomes. Frailty is one such measure that…
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Keywords:
biomarker lifespan;
lifespan healthspan;
frailty;
index biomarker ... See more keywords
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Published in 2020 at "NPJ Aging and Mechanisms of Disease"
DOI: 10.1038/s41514-020-0044-8
Abstract: Caloric restriction (CR) is one of the most effective interventions to prolong lifespan and promote health. Recently, it has been suggested that hydrogen sulfide (H2S) may play a pivotal role in mediating some of these…
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Keywords:
healthspan benefits;
exogenous h2s;
lifespan healthspan;
benefits exogenous ... See more keywords
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Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13589
Abstract: Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in ageārelated NAD decline. Whether the inhibition of CD38 increases lifespan is not known.…
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Keywords:
inhibitor 78c;
increases mice;
cd38;
cd38 inhibitor ... See more keywords
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Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/5958043
Abstract: Carnosol, a phenolic diterpene, is one of the main constituents of Rosmarinus. It is known to possess a range of bioactivities, including antioxidant, anticancer, antimicrobial, and anti-inflammatory properties. Nevertheless, the antiaging effects of carnosol have…
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Keywords:
lifespan healthspan;
caenorhabditis elegans;
improved lifespan;
carnosol improved ... See more keywords