Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions
Sign Up to like & getrecommendations! Published in 2019 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2019.03.005
Abstract: Although survival has been the focus of aging research for many years, the field is rapidly evolving towards incorporating healthspan and health indices in studies that explore aging-related outcomes. Frailty is one such measure that… read more here.
Keywords: biomarker lifespan; lifespan healthspan; frailty; index biomarker ... See more keywords
Lifespan and healthspan benefits of exogenous H2S in C. elegans are independent from effects downstream of eat-2 mutation
Sign Up to like & getrecommendations! Published in 2020 at "NPJ Aging and Mechanisms of Disease"
DOI: 10.1038/s41514-020-0044-8
Abstract: Caloric restriction (CR) is one of the most effective interventions to prolong lifespan and promote health. Recently, it has been suggested that hydrogen sulfide (H2S) may play a pivotal role in mediating some of these… read more here.
Keywords: healthspan benefits; exogenous h2s; lifespan healthspan; benefits exogenous ... See more keywords
CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13589
Abstract: Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in age‐related NAD decline. Whether the inhibition of CD38 increases lifespan is not known.… read more here.
Keywords: inhibitor 78c; increases mice; cd38; cd38 inhibitor ... See more keywords
Carnosol Improved Lifespan and Healthspan by Promoting Antioxidant Capacity in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/5958043
Abstract: Carnosol, a phenolic diterpene, is one of the main constituents of Rosmarinus. It is known to possess a range of bioactivities, including antioxidant, anticancer, antimicrobial, and anti-inflammatory properties. Nevertheless, the antiaging effects of carnosol have… read more here.
Keywords: lifespan healthspan; caenorhabditis elegans; improved lifespan; carnosol improved ... See more keywords