Overexpression of a single ORF can extend chronological lifespan in yeast if retrograde signaling and stress response are stimulated
Sign Up to like & getrecommendations! Published in 2021 at "Biogerontology"
DOI: 10.1007/s10522-021-09924-z
Abstract: Systematic collections of single-gene deletions have been invaluable in uncovering determinants of lifespan in yeast. Overexpression of a single gene does not have such a clear outcome as cancellation of its function but it can… read more here.
Keywords: overexpression; retrograde signaling; overexpression single; chronological lifespan ... See more keywords
Proline metabolism regulates replicative lifespan in the yeast Saccharomyces cerevisiae
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DOI: 10.15698/mic2019.10.694
Abstract: In many plants and microorganisms, intracellular proline has a protective role against various stresses, including heat-shock, oxidation and osmolarity. Environmental stresses induce cellular senescence in a variety of eukaryotes. Here we showed that intracellular proline… read more here.
Keywords: lifespan yeast; intracellular proline; proline; replicative lifespan ... See more keywords