Associations Between Maternal Lifetime Stress and Placental Mitochondrial DNA Mutations in an Urban Multiethnic Cohort
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DOI: 10.1016/j.biopsych.2020.09.013
Abstract: BACKGROUND Disrupted placental functioning due to stress can have lifelong implications. Cumulative stress and trauma are likely to have lasting impacts on maternal physiological functioning and offspring development, resulting in increased risk for later-life complex… read more here.
Keywords: lifetime stress; placental mitochondrial; maternal lifetime; stress ... See more keywords
Maternal Lifetime Stress and Prenatal Psychological Functioning and Decreased Placental Mitochondrial DNA Copy Number in the PRISM Study
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DOI: 10.1093/aje/kwx183
Abstract: Psychosocial stress contributes to placental oxidative stress. Mitochondria are vulnerable to oxidative stress, which can lead to changes in mitochondrial DNA copy number (mtDNAcn). We examined associations of maternal lifetime stress, current negative life events,… read more here.
Keywords: lifetime stress; mtdnacn; copy number; dna copy ... See more keywords