LncRNA LIFR‐AS1 overexpression suppressed the progression of serous ovarian carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24570
Abstract: Serous ovarian carcinoma (SOC) is a common malignant tumor in female reproductive system. Long noncoding RNA (lncRNA) LIFR‐AS1 is a tumor suppressor gene in colorectal cancer, but its effect and underlying mechanism in SOC are… read more here.
Keywords: lifr as1; serous ovarian; lncrna lifr; ovarian carcinoma ... See more keywords
Altered expression of leukemia inhibitory factor (LIF), LIFR, gp130, and IL11 in the embryo implantation site of rat model with prenatal androgen-induced polycystic ovary syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.03.053
Abstract: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that represents infertility in many reproductive-age women. Reduced implantation of blastocyst was proposed as an etiology for infertility in this syndrome. In this regard, many candidate… read more here.
Keywords: lifr; lif lifr; expression; lif ... See more keywords
The role of adiposity in enhancing LIF/LIFR signaling pathway in endometrial cancer
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic Oncology"
DOI: 10.1016/s0090-8258(21)01228-2
Abstract: Objectives: The incidence of endometrial cancer (EC) is estimated to increase by 1-2% annually. More than half of all EC diagnoses are currently attributable to obesity, which is an independent risk factor for this cancer.… read more here.
Keywords: lifr; lifr signaling; adiposity; tissue ... See more keywords
Harnessing the Estradienone Scaffold to Develop Dual GPBAR1 and LIFR Modulators for Liver Fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.5c00705
Abstract: Fibrosis is a pathological process characterized by excessive deposition of the extracellular matrix (ECM) within tissues. Chronic fibrotic disorders involving the lungs, liver, intestine, and kidneys represent a major cause of morbidity and mortality and… read more here.
Keywords: lifr; harnessing estradienone; estradienone scaffold; liver fibrosis ... See more keywords
EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-18-1258
Abstract: Leukemia inhibitory factor receptor (LIFR) and its ligand LIF play a critical role in cancer progression, metastasis, stem cell maintenance, and therapy resistance. Here, we describe a rationally designed first-in-class inhibitor of LIFR, EC359, which… read more here.
Keywords: negative breast; lifr; cancer; lif lifr ... See more keywords
Abstract 5986: Significance of LIF/LIFR axis in the progression of inflammatory breast cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5986
Abstract: Background: Inflammatory breast cancer (IBC) is a rare form of locally progressed breast cancer. Even though it is uncommon, IBC accounts for 7% of breast cancer deaths. There is a critical need for novel therapeutic… read more here.
Keywords: cancer; breast cancer; lifr; lif lifr ... See more keywords
Abstract 1630: Targeting the LIF/LIFR axis reduces the progression of inflammatory breast cancer by promoting ferroptosis
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1630
Abstract: Inflammatory breast cancer (IBC) is a rare subtype of breast cancer affecting 2-4% of the U.S. population. With the incidence being quite low, IBC is responsible for 7% of breast cancer related mortality often affecting… read more here.
Keywords: cancer; breast cancer; lifr; lif lifr ... See more keywords
Pan-cancer analysis identifies LIFR as a prognostic and immunological biomarker for uterine corpus endometrial carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1118906
Abstract: Background Leukemia inhibitory factor (LIF) exhibits significant tumor-promoting function, while its cognate receptor (LIFR) is considered to act as either a tumor promoter or suppressor. Dysregulation of LIF and LIFR is associated with the initiation,… read more here.
Keywords: lifr expression; lifr; expression; correlations lifr ... See more keywords
LIFR-Mediated ERBB2 Signaling Is Essential for Successful Embryo Implantation in Mice
Sign Up to like & getrecommendations! Published in 2025 at "Biomolecules"
DOI: 10.3390/biom15050698
Abstract: In eutherian mammals, embryo implantation is a critical process for a successful pregnancy. In mice, the activation of the leukemia inhibitory factor (LIF) receptor–STAT3 signaling axis induces embryo adhesion and decidualization. The LIF receptor is… read more here.
Keywords: mice; lifr; embryo implantation; implantation ... See more keywords
Inhibition of LIFR Blocks Adiposity-Driven Endometrioid Endometrial Cancer Growth
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14215400
Abstract: Simple Summary In this study, we utilized global RNA-seq to elucidate the molecular mechanisms by which obese conditions promote progression of endometrioid endometrial cancer (EEC). Our results suggest that obese conditions upregulate LIF/LIFR signaling, and… read more here.
Keywords: endometrial cancer; progression; lif lifr; eec ... See more keywords