Heparin functionalization increases retention of TGF-β2 and GDF5 on biphasic silk fibroin scaffolds for tendon/ligament-to-bone tissue engineering.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.03.017
Abstract: The tendon/ligament-to-bone transition (enthesis) is a highly specialized interphase tissue with structural gradients of extracellular matrix composition, collagen molecule alignment and mineralization. These structural features are essential for enthesis function, but are often not regenerated… read more here.
Keywords: ligament bone; enthesis; tissue; bone ... See more keywords
A triple-coated ligament graft to facilitate ligament-bone healing by inhibiting fibrogenesis and promoting osteogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.07.054
Abstract: Absence of ligament-bone healing due to poor bioactivity and hyperplasia of fibrous tissue caused by immune response severely impairs ligament grafts' functional duration in anterior cruciate ligament (ACL) reconstruction. While osteogenic modification is a popular… read more here.
Keywords: ligament bone; ligament; graft; bone healing ... See more keywords
Biomimetic strategies for tendon/ligament-to-bone interface regeneration
Sign Up to like & getrecommendations! Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2021.01.022
Abstract: Tendon/ligament-to-bone healing poses a formidable clinical challenge due to the complex structure, composition, cell population and mechanics of the interface. With rapid advances in tissue engineering, a variety of strategies including advanced biomaterials, bioactive growth… read more here.
Keywords: ligament bone; strategies tendon; regeneration; tendon ligament ... See more keywords
Mechanobiology of the Ligament to Bone Insertion
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2313
Abstract: The interface between materials with mismatched elastic moduli is failure-prone due to singular stress concentrations that could develop at the interface. Yet most ligaments tear at mid-substance and not at the ligament-bone interface. Current physiological… read more here.
Keywords: ligament bone; interface; geometry; bone interface ... See more keywords
Phytic Acid-Gallium Network on a Polyimide Fiber Woven Fabric as an Artificial Ligament for Boosting Ligament-Bone Healing and Infection Treatment.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c08621
Abstract: The development of an artificial ligament with a multifunction of promoting bone formation, inhibiting bone resorption, and preventing infection to obtain ligament-bone healing for anterior cruciate ligament (ACL) reconstruction still faces enormous challenges. Herein, a… read more here.
Keywords: bone healing; ligament; ligament bone; infection ... See more keywords
Outcomes after Bone-Ligament-Bone Intercarpal Ligament Reconstruction
Sign Up to like & getrecommendations! Published in 2022 at "Plastic and Reconstructive Surgery"
DOI: 10.1097/prs.0000000000008955
Abstract: Background: Numerous surgical reconstructive techniques have been described for chronic scapholunate and lunotriquetral interosseous ligament instability. Methods: The authors retrospectively reviewed 16 consecutive patients who underwent bone-ligament-bone reconstruction for scapholunate or lunotriquetral intraosseous ligament predynamic… read more here.
Keywords: ligament bone; ligament; bone; bone reconstruction ... See more keywords