Osteoprotegerin is sensitive to actomyosin tension in human periodontal ligament fibroblasts
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30256
Abstract: Periodontal ligament fibroblasts (PdLFs) are an elongated cell type in the periodontium with matrix and bone regulatory functions which become abnormal in periodontal disease (PD). Here we found that the normally elongated and oriented PdLF… read more here.
Keywords: actomyosin tension; periodontal ligament; osteoprotegerin sensitive; ligament fibroblasts ... See more keywords
The effect of interleukin-22 on osteogenic differentiation and the osteoclastogenic response of Human periodontal ligament fibroblasts in vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of periodontology"
DOI: 10.1002/jper.19-0470
Abstract: BACKGROUND Interleukin-22 (IL-22) exerts extensive biological effects, playing both protective and pathological roles in autoimmune and infectious diseases. However, the specific role and mechanism of IL-22 in the pathogenesis of periodontitis have not been clarified.… read more here.
Keywords: expression; periodontal ligament; human periodontal; interleukin ... See more keywords
Periodontal ligament fibroblasts regulate osteoblasts by exosome secretion induced by inflammatory stimuli.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2019.06.002
Abstract: OBJECTIVES This study evaluated the role of human periodontal ligament fibroblasts (hPDLFs)-derived exosomes in periodontitis progression and discovered whether hPDLFs influence bone remodeling activity via exosome secretion. MATERIALS AND METHODS Exosomes were isolated and quantified… read more here.
Keywords: periodontal ligament; ligament fibroblasts; secretion; gw4869 ... See more keywords
Construction of micro-grooved PCL/nanohydroxyapatite membranes by non-solvent induced phase separation method and its evaluation for use as a substrate for human periodontal ligament fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Engineering Science"
DOI: 10.1016/j.ces.2021.117120
Abstract: Abstract Micro-patterned membrane constructs based on neat, and nanohydroxyapatite (HA)-blended poly(e-caprolactone) were developed using the phase separation micro-molding (PSµM) technique. Physical, chemical, thermal, mechanical and in vitro biological properties of the constructs were evaluated. Human… read more here.
Keywords: periodontal ligament; phase separation; ligament fibroblasts; micro ... See more keywords
Bone marrow mesenchymal stem cell-derived extracellular vesicles containing miR-497-5p inhibit RSPO2 and accelerate OPLL.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119481
Abstract: AIMS Muscle and adipose tissue-derived mesenchymal stem cells presented high osteogenic potentials, which modulate osteoblast function through releasing extracellular vesicles (EVs) containing miRNAs. Herein, this study evaluated the function of bone marrow mesenchymal stem cell-derived… read more here.
Keywords: extracellular vesicles; ligament fibroblasts; bmsc evs; mir 497 ... See more keywords
Diabetes Activates Periodontal Ligament Fibroblasts via NF-κB In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Dental Research"
DOI: 10.1177/0022034518755697
Abstract: Diabetes mellitus increases periodontitis and pathogenicity of the oral microbiome. To further understand mechanisms through which diabetes affects periodontitis, we examined its impact on periodontal ligament fibroblasts in vivo and in vitro. Periodontitis was induced… read more here.
Keywords: periodontal ligament; ligament fibroblasts; pdl fibroblasts; vivo ... See more keywords
Autophagy in spinal ligament fibroblasts: evidence and possible implications for ossification of the posterior longitudinal ligament
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-020-02017-6
Abstract: Background The molecular mechanisms of ossification of the posterior longitudinal ligament (OPLL) remain to be elucidated. The aim of the present study was to investigate the autophagy of spinal ligament fibroblasts derived from patients with… read more here.
Keywords: ligament fibroblasts; ossification posterior; spinal ligament; ligament ... See more keywords
479-P: Combination of Trans-resveratrol and Hesperetin Corrects Unscheduled Increased Glucose Metabolism Driving Dysfunction of Human Periodontal Ligament Fibroblasts in Hyperglycemia In Vitro
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-479-p
Abstract: Dysfunction of human periodontal ligament fibroblasts (PDLFs) contributes to increased prevalence and severity of periodontitis in diabetes. Hyperglycemia induces multiple pathways of metabolic dysfunction: mitochondrial dysfunction, hexosamine and protein kinase C pathway activation and increased… read more here.
Keywords: periodontal ligament; ligament fibroblasts; dysfunction human; dysfunction ... See more keywords
Mapping of DNA methylation-sensitive cellular processes in gingival and periodontal ligament fibroblasts in the context of periodontal tissue homeostasis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1078031
Abstract: Interactions between gingival fibroblasts (GFs) and oral pathogens contribute to the chronicity of inflammation in periodontitis. Epigenetic changes in DNA methylation are involved in periodontitis pathogenesis, and recent studies indicate that DNA methyltransferase (DNMT) inhibitors… read more here.
Keywords: methylation; ligament fibroblasts; dna methylation; dac ... See more keywords
The protective effect of 17 β-estradiol on human uterosacral ligament fibroblasts from postmenopausal women with pelvic organ prolapse
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.980843
Abstract: This study aims to explore the protective effects of 17 β-estradiol on the human uterosacral ligament fibroblasts (hUSLFs) under static or stretched conditions. The experiments were performed on hUSLFs derived from pelvic organ prolapse (POP)… read more here.
Keywords: cell; estradiol human; human uterosacral; ligament fibroblasts ... See more keywords
High-Glucose Media Reduced the Viability and Induced Differential Pro-Inflammatory Cytokines in Human Periodontal Ligament Fibroblasts
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13040690
Abstract: Hyperglycemic condition in diabetic patients tends to exacerbate periodontitis severity. Thus, the influence of hyperglycemia on the biological and inflammatory response of periodontal ligament fibroblasts (PDLFs) needs to be elucidated. In this study, PDLFs were… read more here.
Keywords: ligament fibroblasts; inflammatory cytokines; inflammatory; pro inflammatory ... See more keywords