MiR‐615‐3p inhibits the osteogenic differentiation of human lumbar ligamentum flavum cells via suppression of osteogenic regulators GDF5 and FOXO1
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DOI: 10.1002/cbin.10780
Abstract: Ossification of the ligamentum flavum (OLF) is a disease of heterotopic ossification in spinal ligaments. The key of the OLF pathogenesis is the differentiation of fibroblasts into osteoblasts. In this study, we explored the role… read more here.
Keywords: differentiation human; ligamentum flavum; differentiation; osteogenic differentiation ... See more keywords
Association analysis and functional study of COL6A1 single nucleotide polymorphisms in thoracic ossification of the ligamentum flavum in the Chinese Han population
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DOI: 10.1007/s00586-021-06932-y
Abstract: Genetic factors play a crucial role in thoracic ossification of the ligamentum flavum (TOLF). This study aimed to better understand the association between single nucleotide polymorphisms (SNP) in functional regions of the collagen VI, alpha… read more here.
Keywords: tolf; col6a1; expression; ligamentum flavum ... See more keywords
Thoracic ossification of ligamentum flavum manifesting holocord syringomyelia: case report
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-018-3492-1
Abstract: It has been reported that syringomyelia is rarely associated with degenerative spinal disorders, but the case of holocord syringomyelia is never reported. We here present a case of a 59-year-old woman with right shoulder pain,… read more here.
Keywords: ossification ligamentum; ligamentum flavum; case; holocord syringomyelia ... See more keywords
Numerical investigation of the relative effect of disc bulging and ligamentum flavum hypertrophy on the mechanism of central cord syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical biomechanics"
DOI: 10.1016/j.clinbiomech.2020.02.008
Abstract: BACKGROUND The pathogenesis of the central cord syndrome is still unclear. While there is a consensus on hyperextension as the main traumatic mechanism leading to this condition, there is yet to be consensus in studies… read more here.
Keywords: flavum hypertrophy; ligamentum flavum; flavum; central cord ... See more keywords
Changes of MRI in inter-spinal distraction fusion for lumbar degenerative disease: A retrospective analysis covering 3 years
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DOI: 10.1016/j.jocn.2020.10.011
Abstract: OBJECTIVE To assess the preoperative and postoperative changes in MRI image and the short-term efficacy of the ISDF with BacFuse covering 3 years. METHODS 32 patients who underwent ISDF were involved in this retrospective study. The… read more here.
Keywords: covering years; ligamentum flavum; herniated disc; area ... See more keywords
The role of JAK-STAT signalling activation in hypertrophied ligamentum flavum.
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DOI: 10.1016/j.wneu.2020.02.024
Abstract: OBJECTIVE Although previous studies have reported the expression of JAK1, STAT3 and phosphorylated p-STAT3 in hypertrophied ligamentum flavum (LF), the role of the JAK/STAT signalling pathway in hypertrophied LF has not been fully elucidated. The… read more here.
Keywords: jak; ligamentum flavum; jak stat; stat signalling ... See more keywords
Comparison of Surgical Outcomes Between Staged and Simultaneous Decompression of Discontinuous Thoracic Ossification of the Ligamentum Flavum: A Retrospective Study.
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DOI: 10.1016/j.wneu.2021.07.075
Abstract: BACKGROUND Discontinuous thoracic ossification of the ligamentum flavum (TOLF) is diagnosed according to the number and distribution of involved segments seen on magnetic resonance images. When TOLF causes thoracic myelopathy, surgical intervention for these lesions… read more here.
Keywords: decompression discontinuous; decompression; discontinuous thoracic; ossification ligamentum ... See more keywords
Fibroblast Growth Factor 9 Is Upregulated Upon Intervertebral Mechanical Stress-Induced Ligamentum Flavum Hypertrophy in a Rabbit Model.
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DOI: 10.1097/brs.0000000000003089
Abstract: STUDY DESIGN Case-control study of an animal model. OBJECTIVE To investigate the factors that are upregulated and potentially related to degenerative changes in the ligamentum flavum (LF) upon mechanical stress concentration. SUMMARY OF BACKGROUND DATA… read more here.
Keywords: hypertrophy; upon mechanical; fibroblast growth; stress ... See more keywords
Indirect Decompression Effect to Central Canal and Ligamentum Flavum After Extreme Lateral Lumbar Interbody Fusion (XLIF) and Oblique Lumbar Interbody Fusion (OLIF).
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DOI: 10.1097/brs.0000000000003521
Abstract: STUDY DESIGN A retrospective study (level of evidence: level 4) OBJECTIVE.: To evaluate the radiographic outcomes after XLIF and OLIF procedures especially the effect of indirect decompression to the ligamentum flavum and to evaluate the… read more here.
Keywords: lumbar interbody; lumbar; interbody fusion; ligamentum flavum ... See more keywords
Macrophage migration inhibitory factor may contribute to hypertrophy of lumbar ligamentum flavum in type 2 diabetes mellitus
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DOI: 10.1097/cm9.0000000000000680
Abstract: Previous studies have implicated the proinflammatory To the Editor: Lumbar spinal canal stenosis (LSCS) is a common disease among older individuals. Hypertrophic factors including interleukin (IL)-1a, IL-6, tumor necrosis lumbar ligamentum flavum (LLF) plays a… read more here.
Keywords: llf; ligamentum flavum; lumbar ligamentum;
LGR5 regulates osteogenic differentiation of human thoracic ligamentum flavum cells by Wnt signalling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17420
Abstract: Thoracic ossification of the ligamentum flavum (TOLF) is ectopic ossification of the spinal ligaments. Histologically, the development of TOLF can be described as the process of endochondral ossification. However, the underlying aetiology has not been… read more here.
Keywords: lgr5; osteogenic differentiation; wnt signalling; ligamentum flavum ... See more keywords