αN-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers
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DOI: 10.3390/ijms24010582
Abstract: The opioid peptide β-endorphin coexists in the pituitary and brain in its αN-acetylated form, which does not bind to opioid receptors. We now report that these neuropeptides exhibited opposite effects in in vivo paradigms, in… read more here.
Keywords: acetyl endorphin; opioid receptor; endorphin endogenous; endogenous ligand ... See more keywords