Inhibition of tumorigenesis by peroxisome proliferator-activated receptor (PPAR)-dependent cell cycle blocks in human skin carcinoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology"
DOI: 10.1016/j.tox.2018.05.003
Abstract: To examine the functional role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) and PPARγ in skin cancer, stable cell lines were created in the A431 human squamous cell carcinoma cell line. Expression of PPAR target genes was… read more here.
Keywords: ppar; ligand activation; ppar ppar; expression ... See more keywords
Iridium(III) bis(thiophosphinite) pincer complexes: synthesis, ligand activation and applications in catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "Dalton transactions"
DOI: 10.1039/d2dt01633h
Abstract: Iridium(III) bis(thiophosphinite) complexes of the type [(RPSCSPR)Ir(H)(Cl)(py)] (RPSCSPR = κ3-(2,6-SPR2)C6H3) (R = tBu, iPr, Ph) can be prepared from the ligand precursors 1,3-(SPR2)C6H4 by C-H activation at Ir using [Ir(COE)2Cl]2 or [Ir(COD)Cl]2. Optimisation of the… read more here.
Keywords: bis thiophosphinite; ligand activation; presence; iridium iii ... See more keywords
The mechanism for ligand activation of the GPCR–G protein complex
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2110085119
Abstract: Significance We report the detailed atomistic mechanism for how molecules such as morphine, dopamine, or epinephrine binding outside of a cell to a G protein–coupled receptor (GPCR) in the cell membrane cause a G protein… read more here.
Keywords: ligand activation; mechanism; mechanism ligand; activation gpcr ... See more keywords
Editor’s Highlight: PPAR&bgr;/&dgr; and PPAR&ggr; Inhibit Melanoma Tumorigenicity by Modulating Inflammation and Apoptosis
Sign Up to like & getrecommendations! Published in 2017 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfx147
Abstract: Skin tumorigenesis results from DNA damage, increased inflammation, and evasion of apoptosis. The peroxisome proliferator-activated receptors (PPARs) can modulate these mechanisms in non-melanoma skin cancer. However, limited data exists regarding the role of PPARs in… read more here.
Keywords: ppar; ligand activation; ppar ppar; compared controls ... See more keywords