Multi-scale computational investigations of ligand association pathways: Case of p38 MAP kinase and its inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.08.026
Abstract: Protein kinases are one of the most important drug targets in the past ten years. Understanding the inhibitor association processes will profoundly impact new binder designs with preferred binding kinetics. However, after more than a… read more here.
Keywords: inhibitor binding; ligand association; inhibitor; kinase ... See more keywords
Enhancement of RNA/Ligand Association Kinetics via an Electrostatic Anchor
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00231
Abstract: The diverse biological processes mediated by RNA rest upon its recognition of various ligands, including small molecules and nucleic acids. Nevertheless, a recent literature survey suggests that RNA molecular recognition of these ligands is slow,… read more here.
Keywords: ligand association; via electrostatic; association; rna ligand ... See more keywords