Structural Models of Ligand-Bound Sodium Channels.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_44
Abstract: X-ray and cryo-EM structures of tetrameric and pseudo-tetrameric P-loop channels are used to elaborate homology models of mammalian voltage-gated sodium channels with drugs and neurotoxins. Such models integrate experimental data, assist in planning new experiments,… read more here.
Keywords: models ligand; structural models; sodium; bound sodium ... See more keywords
Interactions between ligand-bound EGFR and VEGFR2.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167006
Abstract: In this work, we put forward the provocative hypothesis that the active, ligand-bound RTK dimers from unrelated subfamilies can associate into heterooligomers with novel signaling properties. This hypothesis is based on a quantitative FRET study… read more here.
Keywords: egfr vegfr2; presence; interactions ligand; bound egfr ... See more keywords
Ligand-bound integrin αvβ6 internalisation and trafficking
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DOI: 10.3389/fcell.2022.920303
Abstract: The integrin αvβ6 is expressed at low levels in most normal healthy tissue but is very often upregulated in a disease context including cancer and fibrosis. Integrins use endocytosis and trafficking as a means of… read more here.
Keywords: cancer fibrosis; internalisation; bound integrin; ligand ... See more keywords
Kinetics of free and ligand-bound atacicept in human serum
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1035556
Abstract: BAFF (B cell activation factor of the TNF family/B lymphocyte stimulator, BLyS) and APRIL (a proliferation-inducing ligand) are targeted by atacicept, a decoy receptor consisting of the extracellular domain of TACI (transmembrane activator and calcium-modulator… read more here.
Keywords: free ligand; baff; atacicept human; serum ... See more keywords