Kinetic Resolution of Alkylidene Norcamphors via a Ligand-Controlled Umpolung-Type 1,3-Dipolar Cycloaddition
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2018.12.010
Abstract: Summary Development of a general catalytic and highly efficient method utilizing readily available precursors for the regio- and stereoselective construction of bioactive natural-product-inspired spiro architectures remains a formidable challenge in chemical research. Transition metal-catalyzed asymmetric… read more here.
Keywords: ligand controlled; cycloaddition; dipolar cycloaddition; kinetic resolution ... See more keywords
Ligand-controlled phosphine-free Co(II)-catalysed cross-coupling of secondary and primary alcohols
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.130640
Abstract: Abstract Cobalt(II) complexes (5 mol% Co) bearing phosphine-free N˄N˄N pincer ligands efficiently catalyze C–C coupling of secondary and primary alcohols to selectively form α-alkylated ketones with a good functional group compatibility using NaOH (20 mol%) as a… read more here.
Keywords: secondary primary; coupling secondary; controlled phosphine; ligand controlled ... See more keywords
Ligand-Controlled Chemoselectivity in Manganese-Catalyzed Coupling of Benzyl Alcohol with Phosphorus Ylide: A Theoretical Study.
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DOI: 10.1021/acs.inorgchem.5c04327
Abstract: The selective formation of C-C and C═C bonds is fundamentally important in pharmaceutical synthesis and materials science. Herein, the ligand-controlled chemoselectivity of the Mn-catalyzed coupling of benzyl alcohol (BnOH) with a phosphorus ylide for the… read more here.
Keywords: coupling benzyl; ligand controlled; controlled chemoselectivity; ligand ... See more keywords
Cobalt-Catalyzed Ligand-Controlled Divergent Regioselective Reactions of 1,6-Enynes with Thiols
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DOI: 10.1021/acs.organomet.0c00179
Abstract: An efficient cobalt-catalyzed method for the synthesis of carbocyclic organosulfur compounds from 1,6-enynes and thiols has been developed. The significance of this methodology is the ability to gi... read more here.
Keywords: divergent regioselective; controlled divergent; enynes thiols; cobalt catalyzed ... See more keywords
Ligand-Controlled Palladium-Catalyzed Chemoselective Multicomponent Reaction of Olefin-Tethered Aryl Halides, Isocyanides, and Carboxylic Acids: Diversified Synthesis of Imides.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02297
Abstract: The first palladium-catalyzed, ligand-controlled chemoselective synthesis of imides has been achieved. An orthogonal set of conditions has been developed for multicomponent reaction of various olefin-tethered aryl iodides, isocyanides, and carboxylic acids. Alkylimides ("cyclization on" products)… read more here.
Keywords: olefin tethered; multicomponent reaction; synthesis imides; palladium catalyzed ... See more keywords
Ligand-Controlled Palladium-Catalyzed Asymmetric [4+3] and [2+3] Annulation Reactions of Spirovinylcyclopropyl Oxindoles with o-Quinone Methides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01137
Abstract: We herein report regiodivergent ligand-controlled palladium-catalyzed asymmetric cycloaddition reactions between spirovinylcyclopropyl oxindoles and o-quinone methides. Specifically, by using the chiral P,P-ligand Segphos (L5), we obtained various spirooxindole-3,4-benzo[b]oxepanes in moderate to good yields with excellent enantioselectivities… read more here.
Keywords: spirovinylcyclopropyl oxindoles; palladium catalyzed; catalyzed asymmetric; controlled palladium ... See more keywords
Palladium-Catalyzed Nucleophilic Reaction of Alkylidenecyclopropanes with β,γ-Unsaturated α-Ketoesters: Ligand-Controlled Divergent Synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02839
Abstract: A palladium-catalyzed ligand-controlled selective 1,4-addition and cycloaddition reaction of β,γ-unsaturated α-ketoesters with alkylidenecyclopropanes (ACPs) has been developed. Using ACPs and β,γ-unsaturated α-ketoesters as starting materials, γ-dienyl-α-ketoesters and dihydro-2H-pyrans could be prepared selectively by modulating the… read more here.
Keywords: catalyzed nucleophilic; unsaturated ketoesters; palladium catalyzed; ligand controlled ... See more keywords
Ligand-Controlled Nickel-Catalyzed Tandem Isomerization/Regiodivergent Hydroheteroarylation of α-Alkenes with Heteroarenes.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03689
Abstract: We herein describe an accessible ligand-controlled nickel-catalyzed tandem isomerization/regiodivergent hydroheteroarylation of α-alkenes with a series of heteroarenes, wherein the NHC ligand of heteroleptic Ni(II) complexes of the type Ni(NHC)[P(OEt)3]Br2 displayed significant effects on regulation. In… read more here.
Keywords: catalyzed tandem; controlled nickel; nickel catalyzed; isomerization ... See more keywords
Ligand-Controlled Nickel-Catalyzed Reactions of Benzocyclobutenones with Alkynyltrifluoroborates: Diverse Construction of Polysubstituted Naphthols.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c01091
Abstract: Ligand-controlled nickel-catalyzed selective cleavage of the C1-C2 or C1-C8 bond of benzocyclobutenones (BCBs) is reported. The delicate selection of dpppe or PMe3 as the ligand led to predictably divergent synthesis of a wide range of… read more here.
Keywords: controlled nickel; nickel catalyzed; catalyzed reactions; ligand ... See more keywords
Oxygen-Dependent Ligand-Controlled Iron-Catalyzed Chemoselective Synthesis of Olefins and Vinyl Nitriles.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c00455
Abstract: An oxygen-dependent ligand-controlled chemoselective synthesis of vinyl nitriles and E-olefins by coupling a variety of alcohols and benzyl cyanides, catalyzed by a well-characterized, air-stable, easy-to-prepare Fe(II) catalyst (1a) bearing a redox-active arylazo pincer (L1a) is… read more here.
Keywords: dependent ligand; oxygen dependent; ligand controlled; ligand ... See more keywords
Ligand-Controlled Enantioselective and Regiodivergent Construction of 1,2- and 1,3-Disubstituted Alicycles.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c02975
Abstract: Three-dimensional alicyclic skeletons with multiple stereochemically defined chiral centers are highly valuable in modern drug discovery. Here, we reported a diverse approach to access 1,2- and 1,3-disubstituted chiral cycloalkanes by the strategy of NiH-catalyzed, transannular-directed… read more here.
Keywords: regiodivergent construction; ligand controlled; construction disubstituted; enantioselective regiodivergent ... See more keywords