Multisite Labeling of Proteins Using the Ligand-Directed Reactivity of Triggerable Michael Acceptors.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.3c00155
Abstract: Targeted modification of endogenous proteins without genetic manipulation of protein expression machinery has a range of applications from chemical biology to drug discovery. Despite being demonstrated to be effective in various applications, target-specific protein labeling… read more here.
Keywords: triggerable michael; ligand directed; ligand; reactivity ... See more keywords
Discovery and Characterization of Novel BLIMP-1 Heterobifunctional Ligand-Directed Degraders.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c02363
Abstract: B-lymphocyte-induced maturation protein 1 (BLIMP-1/PRDM1) is a master transcriptional repressor essential for terminal differentiation of activated B-cells into bone-marrow resident plasma cells. Multiple myeloma (MM) is a plasma cell malignancy wherein the BLIMP-1 regulon remains… read more here.
Keywords: heterobifunctional ligand; cell; ligand directed; blimp heterobifunctional ... See more keywords
Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development.
Sign Up to like & getrecommendations! Published in 2021 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00285
Abstract: Ligand-directed bioconjugation strategies have been used for selective protein labeling in live cells or tissue samples in applications such as live-cell imaging. Here we hypothesized that a similar strategy could be used for targeted protein… read more here.
Keywords: degradation; acyl alkylsulfonamide; chemistry; acylation ... See more keywords
Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c08853
Abstract: Electrophiles for covalent inhibitors that are suitable for in vivo administration are rare. While acrylamides are prevalent in FDA-approved covalent drugs, chloroacetamides are considered too reactive for such purposes. We report sulfamate-based electrophiles that maintain… read more here.
Keywords: electrophiles covalent; chemistry; ligand directed; sulfamate ... See more keywords
Ligand-Directed Self-Assembly of Organic-Semiconductor/Quantum-Dot Blend Films Enables Efficient Triplet Exciton-Photon Conversion
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c00125
Abstract: Blends comprising organic semiconductors and inorganic quantum dots (QDs) are relevant for many optoelectronic applications and devices. However, the individual components in organic-QD blends have a strong tendency to aggregate and phase-separate during film processing,… read more here.
Keywords: semiconductor; blend films; photon; directed self ... See more keywords
Ligand-directed synthesis of {Mn} twisted bow-ties.
Sign Up to like & getrecommendations! Published in 2017 at "Dalton transactions"
DOI: 10.1039/c7dt02430d
Abstract: Two isostructural polymetallic complexes [Mn(μ3-O)2(CH3COO)4(L1)4]- and [Mn(μ3-O)2(CH3COO)4(L2)4]- have been synthesised by using two Schiff base ligands derived from 3,5-diamino-1,2,4-triazole, following two different preparative routes, either using the pre-formed ligand (for L1) or via a metal-mediated… read more here.
Keywords: twisted bow; synthesis twisted; ligand directed; synthesis ... See more keywords
Multi-ligand-directed synthesis of chiral silver nanoclusters.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c7nr06338e
Abstract: Engineering the surface ligands of metal nanoclusters is critical for tuning their sizes, structures and properties at the atomic level. Herein, we report the synthesis and total structure determination of [Ag32(Dppm)5(SAdm)13Cl8]3+ and [Ag45(Dppm)4(S-But)16Br12]3+ (where Dppm… read more here.
Keywords: synthesis chiral; multi ligand; silver nanoclusters; ligand directed ... See more keywords
Orange-emissive carbon quantum dots for ligand-directed Golgi apparatus-targeting and in vivo imaging.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00429a
Abstract: The Golgi apparatus is one of the most important organelles in cells. Targeting and monitoring the morphology and structure of the Golgi apparatus are crucial and challenging. Aimed at the cysteine (Cys) receptor on the… read more here.
Keywords: ligand directed; carbon quantum; apparatus targeting; golgi apparatus ... See more keywords
Bifunctional chimera for ligand-directed photo-degradation of oncogenic microRNA.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06687d
Abstract: Targeted inhibition of oncogenic microRNAs provides a promising anti-cancer approach. Here, we report a bifunctional chimera for ligand-directed regulation of target oncogenic precursor microRNA through photo-degradation. Chimeric TGP-210-Ppa with photosensitizer pyropheophorbide a (Ppa) linked with… read more here.
Keywords: chimera; photo degradation; ligand directed; chimera ligand ... See more keywords
N,N′,N′′ versus N,N′,O imine-containing coordination motifs: ligand-directed synthesis of mononuclear and binuclear CuII compounds
Sign Up to like & getrecommendations! Published in 2017 at "Acta Crystallographica Section E: Crystallographic Communications"
DOI: 10.1107/s2056989017013652
Abstract: It is shown that tridentate imine ligands can control the nuclearity of copper(II) complexes based on the donor atoms present in the ligand. While the N,N′,N′′-donating imine ligand led to a mononuclear compound, the N,N′,O-donating… read more here.
Keywords: coordination motifs; imine containing; containing coordination; ligand directed ... See more keywords
Advancing targeted therapy for colorectal cancer: harnessing ligand-directed enzyme prodrug therapy for highly specific interventions
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2025.1570712
Abstract: Colorectal cancer (CRC) is a significant global health burden, ranking as the third most frequently diagnosed cancer and a leading cause of cancer-related mortality. Current therapeutic modalities face challenges in advanced stages, including drug resistance,… read more here.
Keywords: colorectal cancer; cancer; therapy; directed enzyme ... See more keywords