Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology
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DOI: 10.1021/acs.jmedchem.2c00154
Abstract: Macrocyclic peptides can disrupt previously intractable protein–protein interactions (PPIs) relevant to oncology targets such as KRAS. Early hits often lack cellular activity and require meticulous improvement of affinity, permeability, and metabolic stability to become viable… read more here.
Keywords: identification system; macrocyclic peptides; ligand identification; identification ... See more keywords