Articles with "ligand independent" as a keyword



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Variant BMP receptor mutations causing fibrodysplasia ossificans progressiva (FOP) in humans show BMP ligand-independent receptor activation in zebrafish.

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Published in 2018 at "Bone"

DOI: 10.1016/j.bone.2018.01.002

Abstract: The large majority of cases of the autosomal dominant human disease fibrodysplasia ossificans progressiva (FOP) are caused by gain-of-function Arg206His mutations in the BMP type I receptor ACVR1 (ALK2). The Arg206His mutation is located in… read more here.

Keywords: acvr1 gly328; bmp; ligand independent; bmp ligand ... See more keywords
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Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells.

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Published in 2022 at "Cell reports"

DOI: 10.1016/j.celrep.2022.110583

Abstract: In mature B cells, TACI controls class-switch recombination and differentiation into plasma cells during T cell-independent antibody responses. TACI binds the ligands BAFF and APRIL. Approximately 10% of patients with common variable immunodeficiency (CVID) carry TACI… read more here.

Keywords: activated cells; ligand independent; taci; transmembrane domain ... See more keywords
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Ligand‐independent EphA2 contributes to chemoresistance in small‐cell lung cancer by enhancing PRMT1‐mediated SOX2 methylation

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Published in 2022 at "Cancer Science"

DOI: 10.1111/cas.15653

Abstract: Chemoresistance is the crux of clinical treatment failure of small‐cell lung cancer (SCLC). Cancer stem cells play a critical role in therapeutic resistance of malignant tumors. Studies have shown that the role of erythropoietin‐producing hepatocellular… read more here.

Keywords: ligand independent; small cell; prmt1; epha2 ... See more keywords