Au15Ag3(SPhMe2)14 Nanoclusters – Crystal Structure and Insights into Ligand-Induced Variation
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Inorganic Chemistry"
DOI: 10.1002/ejic.201601513
Abstract: Understanding the ligand effects in the nanocluster (NC) range is crucial for tailoring the properties. We herein report on the crystal structure of the Au15Ag3(SPhMe2)14 nanocluster. Compared with the previously reported Au15Au3(SC6H11)14 nanocluster, Au15Ag3(SPhMe2)14 exhibits… read more here.
Keywords: crystal structure; au15ag3 sphme2; ligand induced; induced variation ... See more keywords
Ligand-induced structural transitions combined with paramagnetic ions facilitate unambiguous NMR assignments of methyl groups in large proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biomolecular NMR"
DOI: 10.1007/s10858-022-00394-0
Abstract: NMR spectroscopy allows the study of biomolecules in close-to-native conditions. Structural information can be inferred from the NMR spectra when an assignment is available. Protein assignment is usually a time-consuming task, being specially challenging in… read more here.
Keywords: methyl groups; induced structural; structural transitions; ligand induced ... See more keywords
Ligand Induced Changes in the Assembly of Nicotinic Receptors
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1626
Abstract: Tobacco smoking is the leading cause of preventable death in the world. Nicotine the primary compound found in tobacco smoke has been found to alter the assembly of some subtypes of nicotinic receptors. Although the… read more here.
Keywords: induced changes; assembly nicotinic; nicotinic receptors; ligand induced ... See more keywords
Ligand-induced glutathione transferase degradation as a therapeutic modality: Investigation of a new metal-mediated affinity cleavage strategy for human GSTP1-1.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.04.187
Abstract: Glutathione transferases (GST, EC. 2.5.1.18) are overexpressed in cancer cell and have been shown to be involved in cancer cell growth, differentiation and the development of multi-drug resistance (MDR) mechanism. Therefore, GST inhibitors are emerging… read more here.
Keywords: degradation; cleavage; human gstp1; ligand induced ... See more keywords
Thermal shift assay: Strengths and weaknesses of the method to investigate the ligand-induced thermostabilization of soluble guanylyl cyclase.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.113065
Abstract: Thermal shift assay is a fluorescence dye based biochemical method to determine the melting point of a protein. It can be used to investigate the ligand-induced stabilization of proteins and helps to increase the likelihood… read more here.
Keywords: shift; shift assay; ligand induced; soluble guanylyl ... See more keywords
Second-harmonic generation-based methods to detect and characterize ligand-induced RNA conformational changes.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.05.012
Abstract: Second-harmonic generation (SHG) is a biophysical tool that senses ligand-induced conformational changes in biomolecules. The Biodesy Delta™ has been developed as a high-throughput screening platform to monitor conformational changes in proteins and oligonucleotides by SHG… read more here.
Keywords: harmonic generation; ligand induced; shg assay; conformational changes ... See more keywords
Ligand-Induced U Mobilization from Chemogenic Uraninite and Biogenic Noncrystalline U(IV) under Anoxic Conditions
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Science & Technology"
DOI: 10.1021/acs.est.1c07919
Abstract: Microbial reduction of soluble hexavalent uranium (U(VI)) to sparingly soluble tetravalent uranium (U(IV)) has been explored as an in situ strategy to immobilize U. Organic ligands might pose a potential hindrance to the success of… read more here.
Keywords: ligand induced; organic ligands; induced mobilization; noncrystalline ... See more keywords
Chemo-Selective Cys-Pen Disulfide for Proximity-Induced Cysteine Cross-Linking.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00083
Abstract: Disulfide-rich architectures are valuable pharmacological tools or therapeutics. Besides, a ligand-induced conjugate strategy offers potential advantages in potency, selectivity, and duration of action for novel covalent drugs. Combining the plentiful disulfide-rich architecture library and ligand-induced… read more here.
Keywords: ligand induced; disulfide; pen disulfide; cys pen ... See more keywords
Generating Potent C-H PCET Donors: Ligand-Induced Fe-to-Ring Proton Migration from a Cp*FeIII-H Complex Demonstrates a Promising Strategy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c09363
Abstract: Highly reactive organometallic species that mediate reductive proton-coupled electron transfer (PCET) reactions are an exciting area for development in catalysis, where a key objective focuses on tuning the reactivity of such species. This work pursues… read more here.
Keywords: feiii; proton; ligand induced; feiii dppe ... See more keywords
Mechanistic Insights into the Ligand-Induced Unfolding of an RNA G-Quadruplex.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c11248
Abstract: The cationic porphyrin TMPyP4 is a well-established DNA G-quadruplex (G4) binding ligand that can stabilize different topologies via multiple binding modes. However, TMPyP4 can have both a stabilizing and destabilizing effect on RNA G4 structures.… read more here.
Keywords: ligand induced; induced unfolding; rna; ligand ... See more keywords
Ligand-Induced G-Quadruplex Polymorphism: A DNA Nanodevice for Label-Free Aptasensor Platforms.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b06533
Abstract: G-Quadruplexes (GQs) serve as popular recognition elements for DNA aptasensors and are incorporated into a DNA nanodevice capable of controlled conformational changes to activate a sensing mechanism. Herein we highlight the utili-ty of a GQ-GQ… read more here.
Keywords: aptasensor; nanodevice; ligand induced; topology ... See more keywords