Lack of functional selectin‐ligand interactions enhances innate immune resistance to systemic Listeria monocytogenes infection
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4a1216-499r
Abstract: Selectin‐ligand interactions are important for leukocyte homing and functionality. The roles of selectin‐ligand interactions in modulating immunity to intracellular infections are not completely understood. Mice lacking the expression of fucosyltransferase‐IV and ‐VII (Fucosyltransferase‐IV and ‐VII… read more here.
Keywords: ligand interactions; innate immune; selectin ligand; infection ... See more keywords
Distal Regions Regulate Dihydrofolate Reductase-Ligand Interactions.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1154-8_12
Abstract: Protein motions play a fundamental role in enzyme catalysis and ligand binding. The relationship between protein motion and function has been extensively investigated in the model enzyme dihydrofolate reductase (DHFR). DHFR is an essential enzyme… read more here.
Keywords: protein; dihydrofolate reductase; ligand interactions; ligand binding ... See more keywords
Synthetic antibody mimics for the inhibition of protein-ligand interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2017.07.001
Abstract: The rational/structure-based design and/or combinatorial development of molecules capable of selectively binding to a protein, represents a promising strategy for a range of biomedical applications, in particular the inhibition of disease-associated protein-ligand interactions. The design… read more here.
Keywords: protein; antibody; ligand interactions; antibody mimics ... See more keywords
Structural insights, protein-ligand interactions and spectroscopic characterization of isoformononetin
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2016.12.043
Abstract: Abstract Isoformononetin, a methoxylated isoflavone present in medicinal plants, has non-estrogenic bone forming effect via differential mitogen-activated protein kinase (MAPK) signaling. Spectroscopic (FT-Raman, FT-IR, UV–vis and NMR spectra) and quantum chemical calculations using density functional… read more here.
Keywords: protein; interactions spectroscopic; structural insights; ligand interactions ... See more keywords
Metal-Ligand Interactions and Their Roles in Controlling Nanoparticle Formation and Functions.
Sign Up to like & getrecommendations! Published in 2023 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.3c00156
Abstract: ConspectusFunctional nanoparticles (NPs) have been studied extensively in the past decades for their unique nanoscale properties and their promising applications in advanced nanosciences and nanotechnologies. One critical component of studying these NPs is to prepare… read more here.
Keywords: control; ligand; reduction; metal ligand ... See more keywords
Elucidating Protein-Ligand Interactions in Cell Lysates Using High-Throughput Hydrogen-Deuterium Exchange Mass Spectrometry with Integrated Protein Thermal Depletion.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04266
Abstract: Hydrogen-deuterium exchange coupled with mass spectrometry (HDX-MS) is a powerful technique for the characterization of protein-ligand interactions. Currently, there is a growing need for breakthroughs in the application of HDX-MS analysis to protein-ligand interactions in… read more here.
Keywords: hdx; high throughput; ligand interactions; cell lysates ... See more keywords
RNA-Ligand Interactions Quantified by Surface Plasmon Resonance with Reference Subtraction.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00177
Abstract: Structured RNAs bind ligands and are attractive targets for small-molecule drugs. A wide variety of analytical methods have been used to characterize RNA-ligand interactions, but our experience is that most have significant limitations in terms… read more here.
Keywords: surface plasmon; subtraction; reference; ligand ... See more keywords
BINANA 2: Characterizing Receptor/Ligand Interactions in Python and JavaScript
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.1c01461
Abstract: BINding ANAlyzer (BINANA) is an algorithm for identifying and characterizing receptor/ligand interactions and other factors that contribute to binding. We recently updated BINANA to make the algorithm more accessible to a broader audience. We have… read more here.
Keywords: receptor ligand; characterizing receptor; binana; ligand interactions ... See more keywords
Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites—Halogenated Probes of Druglike and Peptide-like Molecular Interactions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01357
Abstract: The development of ligands for biological targets is critically dependent on the identification of sites on proteins that bind molecules with high affinity. A set of compounds, called FragLites, can identify such sites, along with… read more here.
Keywords: brd4 atad2; ligand; interactions bromodomains; bromodomains brd4 ... See more keywords
How Significant Are Unusual Protein-Ligand Interactions? Insights from Database Mining.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01545
Abstract: We present a new approach to derive interaction propensities of protein-ligand atom pairs from mining of the Protein Data Bank. To ensure solid statistics, we use a line-of-sight contact filter and normalize the observed frequency… read more here.
Keywords: protein; interactions insights; ligand interactions; significant unusual ... See more keywords
Toward Simple, Predictive Understanding of Protein-Ligand Interactions: Electronic Structure Calculations on Torpedo Californica Acetylcholinesterase Join Forces with the Chemist’s Intuition
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65984-0
Abstract: Contemporary efforts for empirically-unbiased modeling of protein-ligand interactions entail a painful tradeoff – as reliable information on both noncovalent binding factors and the dynamic behavior of a protein-ligand complex is often beyond practical limits. We… read more here.
Keywords: protein; californica acetylcholinesterase; ligand interactions; torpedo californica ... See more keywords