Stabilization and Movable Ligand-Modification by Folate-Appended Polyrotaxanes for Systemic Delivery of siRNA Polyplex.
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DOI: 10.1021/acsmacrolett.2c00462
Abstract: To achieve a systemic targeted delivery of siRNA using polymeric carriers, there is a dilemma between ligand modification and stabilization of the polyplex. Namely, ligand modification often leads to destabilization of the polyplex in the… read more here.
Keywords: sirna; ligand modification; polyplex; delivery sirna ... See more keywords
Increased Targeting Area in Tumors by Dual-Ligand Modification of Liposomes with RGD and TAT Peptides
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DOI: 10.3390/pharmaceutics14020458
Abstract: Modification with polyethylene glycol (PEGylation) and the use of rigid phospholipids drastically improve the pharmacokinetics of chemotherapeutics and result in more manageable or reduced side-effects. A major drawback is retarded cellular delivery of content, which,… read more here.
Keywords: tumor; area; modification; ligand modification ... See more keywords