Polyglycerolated nanocarriers with increased ligand multivalency for enhanced in vivo therapeutic efficacy of paclitaxel.
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DOI: 10.1016/j.biomaterials.2017.08.042
Abstract: Despite the excellent biocompatibility and antifouling effect of poly(ethylene glycol) (PEG), the high steric hindrance, limited chemical functionality, and low ligand multivalency of PEGylated nanocarriers often lead to inefficient cell targeting and intracellular trafficking. Hence,… read more here.
Keywords: ligand multivalency; therapeutic efficacy; ligand; vivo therapeutic ... See more keywords