Extracellular WNTs: Trafficking, Exosomes, and Ligand-Receptor Interaction.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2021_531
Abstract: WNT signaling is a key developmental pathway in tissue organization. A recent focus of research is the secretion of WNT proteins from source cells. Research over the past decade on how WNTs are produced and… read more here.
Keywords: secretion; exosomes ligand; trafficking exosomes; extracellular wnts ... See more keywords
Inference of Ligand-Receptor Pairs from Single-Cell Transcriptomics Data.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/7651_2020_343
Abstract: Cell-cell communication is crucial for development and tissue homeostasis in multicellular organisms. Single-cell transcriptomics has emerged as a revolutionary technique for dissecting cellular compositions and potential cell-cell communication events via ligand-receptor pairs. To provide a… read more here.
Keywords: single cell; communication; cell transcriptomics; ligand receptor ... See more keywords
Characterization of Ligand-Receptor Interactions: Chemotaxis, Biofilm, Cell Culture Assays, and Animal Model Methodologies.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6536-6_13
Abstract: Chemotactic motility is an essential virulence factor for the pathogenesis of Campylobacter spp. infection. In Chapter 6 , we described technologies that enable initial screening and identification of ligands able to interact with chemoreceptor sensory… read more here.
Keywords: receptor interactions; biofilm; ligand receptor; characterization ligand ... See more keywords
On the interpretation of kinetics and thermodynamics probed by single-molecule experiments
Sign Up to like & getrecommendations! Published in 2020 at "Colloid and Polymer Science"
DOI: 10.1007/s00396-020-04662-z
Abstract: Single-molecule pulling experiments are widely used to extract both thermodynamic and kinetic data on ligand-receptor pairs, typically by fitting different models to the probability distribution of rupture forces of the corresponding bond. Here, a theoretical… read more here.
Keywords: single molecule; thermodynamics; bond; ligand receptor ... See more keywords
Adenovirus Mimetic Nanoparticles: Sequential Ligand-Receptor Interplay as a Universal Tool for Enhanced In Vitro/In Vivo Cell Identification.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c10057
Abstract: Viral infection patterns often rely on precisely coordinated sequences of distinct ligand-receptor interactions, leading in many cases to an outstanding target cell specificity. A successful mimicry of viral targeting strategies to create more site-specific nanoparticles… read more here.
Keywords: sequential ligand; adenovirus mimetic; ligand receptor; receptor ... See more keywords
An original approach to measure ligand/receptor binding affinity in non-purified samples
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-09217-6
Abstract: Several biochemical and biophysical methods are available to determine ligand binding affinities between a biological target and its ligands, most of which require purification, labelling or surface immobilisation. These measurements, however, remain challenging in regards… read more here.
Keywords: ligand receptor; membrane; original approach; measure ligand ... See more keywords
Flow driven vesicle unbinding under mechanosensitive adhesion.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d1sm01284c
Abstract: Ligand receptor based adhesion is the primary mode of interaction of cellular blood constituents with the endothelium. These adhered entities also experience shear flow imposed by the blood which may lead to their detachment due… read more here.
Keywords: adhesion; ligand receptor; flow; bond kinetics ... See more keywords
Discovery of new Cdc2-like kinase 4 (CLK4) inhibitors via pharmacophore exploration combined with flexible docking-based ligand/receptor contact fingerprints and machine learning
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra00136e
Abstract: Cdc2-like kinase 4 (CLK4) inhibitors are of potential therapeutic value in many diseases particularly cancer. In this study, we combined extensive ligand-based pharmacophore exploration, ligand–receptor contact fingerprints generated by flexible docking, physicochemical descriptors and machine… read more here.
Keywords: clk4; cdc2 like; ligand receptor; like kinase ... See more keywords
Discovery of new STAT3 inhibitors as anticancer agents using ligand-receptor contact fingerprints and docking-augmented machine learning
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra07007c
Abstract: STAT3 belongs to a family of seven vital transcription factors. High levels of STAT3 are detected in several types of cancer. Hence, STAT3 inhibition is considered a promising therapeutic anti-cancer strategy. In this work, we… read more here.
Keywords: ligand receptor; machine; machine learning; stat3 ... See more keywords
Atomic level and structural understanding of natural ligands inhibiting Helicobacter pylori peptide deformylase through ligand and receptor based screening, SIFT, molecular dynamics and DFT – a structural computational approach
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2050946
Abstract: Abstract Helicobacter pylori is a Gram-negative microaerophilic gastric pathogen, responsible for the cause of peptic ulcer around half of the global population. Although several antibiotics and combination therapies have been employed for H. pylori-related gastric… read more here.
Keywords: ligand receptor; pylori peptide; ligand; helicobacter pylori ... See more keywords
What is the current value of MM/PBSA and MM/GBSA methods in drug discovery?
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2021.1942836
Abstract: The computer-aided drug design field is constituted by a wide range of different approaches that can be roughly classified as either ligandor receptor-based techniques. In order to design and develop new active ligands, ligand-based approaches… read more here.
Keywords: receptor; interaction; ligand receptor; drug discovery ... See more keywords