Extracellular WNTs: Trafficking, Exosomes, and Ligand-Receptor Interaction.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2021_531
Abstract: WNT signaling is a key developmental pathway in tissue organization. A recent focus of research is the secretion of WNT proteins from source cells. Research over the past decade on how WNTs are produced and… read more here.
Keywords: secretion; exosomes ligand; trafficking exosomes; extracellular wnts ... See more keywords
Inference of Ligand-Receptor Pairs from Single-Cell Transcriptomics Data.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/7651_2020_343
Abstract: Cell-cell communication is crucial for development and tissue homeostasis in multicellular organisms. Single-cell transcriptomics has emerged as a revolutionary technique for dissecting cellular compositions and potential cell-cell communication events via ligand-receptor pairs. To provide a… read more here.
Keywords: single cell; communication; cell transcriptomics; ligand receptor ... See more keywords
Characterization of Ligand-Receptor Interactions: Chemotaxis, Biofilm, Cell Culture Assays, and Animal Model Methodologies.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6536-6_13
Abstract: Chemotactic motility is an essential virulence factor for the pathogenesis of Campylobacter spp. infection. In Chapter 6 , we described technologies that enable initial screening and identification of ligands able to interact with chemoreceptor sensory… read more here.
Keywords: receptor interactions; biofilm; ligand receptor; characterization ligand ... See more keywords
On the interpretation of kinetics and thermodynamics probed by single-molecule experiments
Sign Up to like & getrecommendations! Published in 2020 at "Colloid and Polymer Science"
DOI: 10.1007/s00396-020-04662-z
Abstract: Single-molecule pulling experiments are widely used to extract both thermodynamic and kinetic data on ligand-receptor pairs, typically by fitting different models to the probability distribution of rupture forces of the corresponding bond. Here, a theoretical… read more here.
Keywords: single molecule; thermodynamics; bond; ligand receptor ... See more keywords
Adenovirus Mimetic Nanoparticles: Sequential Ligand-Receptor Interplay as a Universal Tool for Enhanced In Vitro/In Vivo Cell Identification.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c10057
Abstract: Viral infection patterns often rely on precisely coordinated sequences of distinct ligand-receptor interactions, leading in many cases to an outstanding target cell specificity. A successful mimicry of viral targeting strategies to create more site-specific nanoparticles… read more here.
Keywords: sequential ligand; adenovirus mimetic; ligand receptor; receptor ... See more keywords
Effect of pH-Responsive Ligands on mRNA Knockdown in EGFR-Targeting Ligand-Conjugated siRNAs.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical biology"
DOI: 10.1021/acschembio.4c00507
Abstract: Ligand-conjugated small interfering RNAs (siRNAs) have emerged as a powerful approach to developing nucleic acid-based medicines. To achieve efficient mRNA knockdown, it is important to select targeting receptors with high expression and ligands that exhibit… read more here.
Keywords: effect; ligand; ligand receptor; mrna knockdown ... See more keywords
Finding spatially variable ligand-receptor interactions with functional support from downstream genes
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62988-0
Abstract: Spatial transcriptomics has emerged as a groundbreaking tool for the study of intercellular ligand-receptor interactions (LRIs) that exhibit spatial variability. To identify spatially variable LRIs with activation evidence, we present SPIDER, which constructs cell-cell interaction… read more here.
Keywords: spatially variable; cell; receptor interactions; ligand receptor ... See more keywords
Connectome-constrained ligand-receptor interaction analysis for understanding brain network communication
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63204-9
Abstract: Both diffusion magnetic resonance imaging and transcriptomic technologies have provided unprecedented opportunities to dissect brain network communication, offering insights from structural connectivity and signaling molecules separately. However, incorporating these complementary modalities for characterizing the interregional… read more here.
Keywords: communication; receptor interaction; brain; ligand receptor ... See more keywords
An original approach to measure ligand/receptor binding affinity in non-purified samples
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-09217-6
Abstract: Several biochemical and biophysical methods are available to determine ligand binding affinities between a biological target and its ligands, most of which require purification, labelling or surface immobilisation. These measurements, however, remain challenging in regards… read more here.
Keywords: ligand receptor; membrane; original approach; measure ligand ... See more keywords
Flow driven vesicle unbinding under mechanosensitive adhesion.
Sign Up to like & getrecommendations! Published in 2022 at "Soft matter"
DOI: 10.1039/d1sm01284c
Abstract: Ligand receptor based adhesion is the primary mode of interaction of cellular blood constituents with the endothelium. These adhered entities also experience shear flow imposed by the blood which may lead to their detachment due… read more here.
Keywords: adhesion; ligand receptor; flow; bond kinetics ... See more keywords
Discovery of new Cdc2-like kinase 4 (CLK4) inhibitors via pharmacophore exploration combined with flexible docking-based ligand/receptor contact fingerprints and machine learning
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra00136e
Abstract: Cdc2-like kinase 4 (CLK4) inhibitors are of potential therapeutic value in many diseases particularly cancer. In this study, we combined extensive ligand-based pharmacophore exploration, ligand–receptor contact fingerprints generated by flexible docking, physicochemical descriptors and machine… read more here.
Keywords: clk4; cdc2 like; ligand receptor; like kinase ... See more keywords