Long-Range Coupled Motions Underlie Ligand Recognition by a Chemokine Receptor
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DOI: 10.1016/j.isci.2020.101858
Abstract: Summary Chemokines are unusual class-A G protein-coupled receptor agonists because of their large size (∼10 kDa) and binding at two distinct receptor sites: N-terminal domain (Site-I, unique to chemokines) and a groove defined by extracellular… read more here.
Keywords: recognition chemokine; ligand recognition; site; receptor ... See more keywords
Structural basis for ligand recognition of the human thromboxane A2 receptor
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DOI: 10.1038/s41589-018-0170-9
Abstract: Stimulated by thromboxane A2, an endogenous arachidonic acid metabolite, the thromboxane A2 receptor (TP) plays a pivotal role in cardiovascular homeostasis, and thus is considered as an important drug target for cardiovascular disease. Here, we… read more here.
Keywords: ligand recognition; thromboxane receptor; receptor; ligand ... See more keywords
Dynamical Behavior of the Human Ferroportin Homologue from Bdellovibrio bacteriovorus: Insight into the Ligand Recognition Mechanism
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DOI: 10.3390/ijms21186785
Abstract: Members of the major facilitator superfamily of transporters (MFS) play an essential role in many physiological processes such as development, neurotransmission, and signaling. Aberrant functions of MFS proteins are associated with several diseases, including cancer,… read more here.
Keywords: ferroportin homologue; mechanism; recognition mechanism; human ferroportin ... See more keywords