Biosensors Monitor Ligand-Selective Effects at Kappa Opioid Receptors.
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DOI: 10.1007/164_2020_427
Abstract: The kappa opioid receptor (KOR) has emerged as a promising therapeutic target for pain and itch treatment. There is growing interest in biased agonists that preferentially activate select signaling pathways downstream of KOR activation on… read more here.
Keywords: kor; biosensors monitor; selective effects; receptor ... See more keywords
Ligand-Selective Wnt Receptor Complexes in CNS Blood Vessels: RECK and GPR124 Plugged In
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DOI: 10.1016/j.neuron.2017.08.026
Abstract: CNS angiogenesis and blood-brain barrier integrity are controlled by the canonical Wnt pathway. In this issue of Neuron, Cho et al. (2017) use advanced mouse genetics and biochemical experiments to unravel the ligand-specific association of membrane… read more here.
Keywords: ligand selective; wnt receptor; blood; receptor complexes ... See more keywords
α-d-Galacturonic Acid as Natural Ligand for Selective Copper-Catalyzed N-Arylation of N-Containing Heterocycles
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DOI: 10.1055/s-0039-1690226
Abstract: The first application of α-d-galacturonic acid hydrate (GalA) is reported here, as a potential O-donor ligand. The C–N couplings of N-heterocycles with aryl halides or arylboronic acids could be readily conducted and exhibited good functional… read more here.
Keywords: selective copper; natural ligand; acid natural; galacturonic acid ... See more keywords