Exploring the Relationship between Nicotinic Acetylcholine Receptor Ligand Size, Efficiency, Efficacy, and C-Loop Opening.
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DOI: 10.1021/acs.jcim.7b00152
Abstract: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels mediating fundamental physiological activities in the nervous system and have become important targets for drug design. For a long time, the acetylcholine binding protein (AChBP) has been… read more here.
Keywords: acetylcholine; ligand; size; ligand size ... See more keywords