Probing Membrane Receptor–Ligand Specificity with Surface- and Tip- Enhanced Raman Scattering
Sign Up to like & getrecommendations! Published in 2017 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.7b01796
Abstract: The specific interaction between a ligand and a protein is a key component in minimizing off-target effects in drug discovery. Investigating these interactions with membrane protein receptors can be quite challenging. In this report, we… read more here.
Keywords: raman scattering; enhanced raman; tip enhanced; surface ... See more keywords
Chimeric LysR-Type Transcriptional Biosensors for Customizing Ligand Specificity Profiles toward Flavonoids.
Sign Up to like & getrecommendations! Published in 2019 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00326
Abstract: Transcriptional biosensors enable key applications in both metabolic engineering and synthetic biology. Due to nature's immense variety of metabolites, these applications require biosensors with a ligand specificity profile customized to the researcher's needs. In this… read more here.
Keywords: biosensor; ligand specificity; specificity profiles; biology ... See more keywords
Nongenetic Reprogramming of the Ligand Specificity of Growth Factor Receptors by Bispecific DNA Aptamers.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b02411
Abstract: The reprogramming of receptor-ligand interactions affords an opportunity to direct cells to respond to user-defined external cues. Although this has often been achieved via the genetic engineering of receptors, an alternative, nongenetic approach is highly… read more here.
Keywords: growth factor; specificity growth; ligand; ligand specificity ... See more keywords
JAZ is essential for ligand specificity of the COI1/JAZ co-receptor
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212155119
Abstract: Significance Phytohormones play a key role in plant environmental adaptation and survival and are perceived by specific receptors. Uncovering the determinants of ligand specificity of hormone receptors is a fundamental scientific question essential to understanding… read more here.
Keywords: jaz receptor; coi1 jaz; jaz; receptor ... See more keywords
Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001714
Abstract: Galanin is a neuropeptide expressed in the central and peripheral nervous systems, where it regulates various processes including neuroendocrine release, cognition, and nerve regeneration. Three G-protein coupled receptors (GPCRs) for galanin have been discovered, which… read more here.
Keywords: structure; galanin; basis ligand; bound galanin ... See more keywords