Ligandability assessment of the C‐terminal Rel‐homology domain of NFAT1
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DOI: 10.1002/ardp.202300649
Abstract: Transcription factors are generally considered challenging, if not “undruggable”, targets but they promise new therapeutic options due to their fundamental involvement in many diseases. In this study, we aim to assess the ligandability of the… read more here.
Keywords: ligandability; terminal rel; rel homology; homology domain ... See more keywords
Ligandability Assessment of Human Glutathione Transferase M1-1 Using Pesticides as Chemical Probes
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DOI: 10.3390/ijms23073606
Abstract: Glutathione transferases (GSTs; EC 2.5.1.18) form a group of multifunctional enzymes that are involved in phase II of the cellular detoxification mechanism and are associated with increased susceptibility to cancer development and resistance to anticancer… read more here.
Keywords: ligandability assessment; glutathione; site; ligand binding ... See more keywords