FRET Studies of Quinolone-Based Bitopic Ligands and Their Structural Analogues at the Muscarinic M1 Receptor.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b00828
Abstract: Aiming to design partial agonists as well as allosteric modulators for the M1 muscarinic acetylcholine (M1AChR) receptor, two different series of bipharmacophoric ligands and their structural analogues were designed and synthesized. The hybrids were composed… read more here.
Keywords: structural analogues; bitopic ligands; linker; receptor ... See more keywords
P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.653561
Abstract: The ionotropic P2X3 receptor (P2X3R) subtype is one of the seven mammalian P2X1-7 receptor belonging to the P2 purinergic receptor family together with the metabotropic P2Y1-2, 4-6,11-14 ones (Fredholm et al., 2011). As the other… read more here.
Keywords: structural features; receptor ligands; p2x3 receptor; receptor ... See more keywords