Activation of TNF‐α/NF‐κB axis enhances CRL4BDCAF 11 E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12176
Abstract: Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3 ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma. Recently, we observed that CUL4B forms the CRL4BDCAF11… read more here.
Keywords: ligase; osteosarcoma; tnf axis; osteosarcoma cells ... See more keywords
Post‐translational modifications of Arabidopsis E3 SUMO ligase AtSIZ1 are controlled by environmental conditions
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12309
Abstract: Sumoylation regulates numerous cellular functions in plants as well as in other eukaryotic systems. However, the regulatory mechanisms controlling E3 small ubiquitin‐related modifier (SUMO) ligase are not well understood. Here, post‐translational modification of the Arabidopsis… read more here.
Keywords: ligase atsiz1; sumo ligase; post translational; arabidopsis sumo ... See more keywords
On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13575
Abstract: Peptide asparaginyl ligases (PALs) are precision tools for peptide cyclization, cell‐surface labelling, protein semisynthesis and protein conjugation. PALs are expressed as inactive proenzymes requiring low pH activation. During activation, a large portion of the cap… read more here.
Keywords: ligase; peptide asparaginyl; protein conjugation; constitutively active ... See more keywords
Chemical Regulation of the Protein Quality Control E3 Ubiquitin Ligase C‐Terminus of Hsc70 Interacting Protein (CHIP)
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202100633
Abstract: The ubiquitin ligase C‐terminus of Hsc70 interacting protein (CHIP) is an important regulator of proteostasis. Despite playing an important role in maintaining proteostasis, little progress has been made in developing small molecules that regulate ubiquitin… read more here.
Keywords: ligase; terminus hsc70; ubiquitin ligase; chip ... See more keywords
The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28971
Abstract: Tripartite motif 8 (TRIM8), an E3 ligase ubiquitously expressed in various cells, is closely involved in innate immunity. However, its role in nonalcoholic steatohepatitis is largely unknown. Here, we report evidence that TRIM8 is a… read more here.
Keywords: trim8; tripartite motif; steatohepatitis; insulin resistance ... See more keywords
The ubiquitin ligase TRIM25 inhibits hepatocellular carcinoma progression by targeting metastasis associated 1 protein
Sign Up to like & getrecommendations! Published in 2017 at "IUBMB Life"
DOI: 10.1002/iub.1661
Abstract: Metastasis associated 1 protein (MTA1) is one of the prime facilitators of metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). However, the underlying regulatory mechanism of MTA1 expression in HCC is not clear.… read more here.
Keywords: protein; expression; trim25; mta1 ... See more keywords
Mitochondrial E3 ubiquitin ligase 1 (MUL1) as a novel therapeutic target for diseases associated with mitochondrial dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2657
Abstract: Mitochondrial E3 ubiquitin ligase 1 (MUL1) is a mitochondrial outer membrane‐anchored protein‐containing transmembrane domain in its N‐ and C‐terminal regions, where both are exposed to the cytosol. Interestingly the C‐terminal region has a RING finger… read more here.
Keywords: associated mitochondrial; ubiquitin ligase; mitochondrial ubiquitin; mul1 ... See more keywords
Identification and characterization of novel ligase I inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22516
Abstract: The terminal step of ligation of single and/or double‐strand breaks during physiological processes such as DNA replication, repair and recombination requires participation of DNA ligases in all mammals. DNA Ligase I has been well characterised… read more here.
Keywords: dna; dna ligase; cancer cells; ligase inhibitors ... See more keywords
Phenolic metabolism in the hornwort Anthoceros agrestis: 4-coumarate CoA ligase and 4-hydroxybenzoate CoA ligase
Sign Up to like & getrecommendations! Published in 2020 at "Plant Cell Reports"
DOI: 10.1007/s00299-020-02552-w
Abstract: 4-Coumarate coenzyme A ligase and 4-hydroxybenzoate coenzyme A ligase from the hornwort Anthoceros agrestis expressed in E. coli were characterized on biochemical and molecular levels and showed interesting substrate specificities. Acyl-activating enzymes are associated with… read more here.
Keywords: coa ligase; anthoceros agrestis; coumaric acid; acid ... See more keywords
Pol I DNA polymerases stimulate DNA end-joining by Escherichia coli DNA ligase.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.165
Abstract: Klenow and Klentaq are the large fragment domains of the Pol I DNA polymerases from Escherichia coli and Thermus aquaticus, respectively. Herein, we show that both polymerases can significantly stimulate complementary intermolecular end-joining ligations by… read more here.
Keywords: end joining; dna; coli dna; dna ligase ... See more keywords
CRL4BRBBP7 targets HUWE1 for ubiquitination and proteasomal degradation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.008
Abstract: The E3 ubiquitin ligase HUWE1/Mule/ARF-BP1 plays an important role in diverse biological processes including DNA damage repair and apoptosis. Our previous study has shown that in response to DNA damage HUWE1 was downregulated in CUL4B-mediated… read more here.
Keywords: dna damage; degradation; huwe1; proteasomal degradation ... See more keywords