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   Articles with "ligase" as a keyword



Activation of TNF‐α/NF‐κB axis enhances CRL4BDCAF 11 E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells

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recommendations! Published in 2018 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12176

Abstract: Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3 ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma. Recently, we observed that CUL4B forms the CRL4BDCAF11… read more here.

Keywords: ligase; osteosarcoma; tnf axis; osteosarcoma cells ... See more keywords

Post‐translational modifications of Arabidopsis E3 SUMO ligase AtSIZ1 are controlled by environmental conditions

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recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12309

Abstract: Sumoylation regulates numerous cellular functions in plants as well as in other eukaryotic systems. However, the regulatory mechanisms controlling E3 small ubiquitin‐related modifier (SUMO) ligase are not well understood. Here, post‐translational modification of the Arabidopsis… read more here.

Keywords: ligase atsiz1; sumo ligase; post translational; arabidopsis sumo ... See more keywords

On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation.

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recommendations! Published in 2023 at "FEBS open bio"

DOI: 10.1002/2211-5463.13575

Abstract: Peptide asparaginyl ligases (PALs) are precision tools for peptide cyclization, cell‐surface labelling, protein semisynthesis and protein conjugation. PALs are expressed as inactive proenzymes requiring low pH activation. During activation, a large portion of the cap… read more here.

Keywords: ligase; peptide asparaginyl; protein conjugation; constitutively active ... See more keywords
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Chemical Regulation of the Protein Quality Control E3 Ubiquitin Ligase C‐Terminus of Hsc70 Interacting Protein (CHIP)

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recommendations! Published in 2022 at "ChemBioChem"

DOI: 10.1002/cbic.202100633

Abstract: The ubiquitin ligase C‐terminus of Hsc70 interacting protein (CHIP) is an important regulator of proteostasis. Despite playing an important role in maintaining proteostasis, little progress has been made in developing small molecules that regulate ubiquitin… read more here.

Keywords: ligase; terminus hsc70; ubiquitin ligase; chip ... See more keywords

A Recognition Tag of Human Origin for Bioorthogonal Generation of Antibody‐Drug Conjugates using Microbial Biotin Ligase

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recommendations! Published in 2025 at "Chembiochem"

DOI: 10.1002/cbic.202500261

Abstract: The use of enzymes, such as microbial transglutaminase, lipoate protein ligase A, or sortase A, for the generation of antibody‐drug conjugates has proven to be a powerful tool for the site‐specific payload conjugation to tumor‐specific… read more here.

Keywords: generation antibody; ligase; p67; mmae ... See more keywords

Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders

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recommendations! Published in 2025 at "Chemmedchem"

DOI: 10.1002/cmdc.202500209

Abstract: Proteolysis targeting chimeras (PROTACs) offer a promising therapeutic approach by leveraging the ubiquitin–proteasome system (UPS) to degrade target proteins. These heterobifunctional molecules consist of a target protein ligand, an E3 ligase ligand, and a linker.… read more here.

Keywords: ligase; tyrosine kinase; ligase ligands; proteolysis targeting ... See more keywords

The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis

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recommendations! Published in 2017 at "Hepatology"

DOI: 10.1002/hep.28971

Abstract: Tripartite motif 8 (TRIM8), an E3 ligase ubiquitously expressed in various cells, is closely involved in innate immunity. However, its role in nonalcoholic steatohepatitis is largely unknown. Here, we report evidence that TRIM8 is a… read more here.

Keywords: trim8; tripartite motif; steatohepatitis; insulin resistance ... See more keywords

The ubiquitin ligase TRIM25 inhibits hepatocellular carcinoma progression by targeting metastasis associated 1 protein

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recommendations! Published in 2017 at "IUBMB Life"

DOI: 10.1002/iub.1661

Abstract: Metastasis associated 1 protein (MTA1) is one of the prime facilitators of metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). However, the underlying regulatory mechanism of MTA1 expression in HCC is not clear.… read more here.

Keywords: protein; expression; trim25; mta1 ... See more keywords

Mitochondrial E3 ubiquitin ligase 1 (MUL1) as a novel therapeutic target for diseases associated with mitochondrial dysfunction

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recommendations! Published in 2022 at "IUBMB Life"

DOI: 10.1002/iub.2657

Abstract: Mitochondrial E3 ubiquitin ligase 1 (MUL1) is a mitochondrial outer membrane‐anchored protein‐containing transmembrane domain in its N‐ and C‐terminal regions, where both are exposed to the cytosol. Interestingly the C‐terminal region has a RING finger… read more here.

Keywords: associated mitochondrial; ubiquitin ligase; mitochondrial ubiquitin; mul1 ... See more keywords

Identification and characterization of novel ligase I inhibitors

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recommendations! Published in 2017 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.22516

Abstract: The terminal step of ligation of single and/or double‐strand breaks during physiological processes such as DNA replication, repair and recombination requires participation of DNA ligases in all mammals. DNA Ligase I has been well characterised… read more here.

Keywords: dna; dna ligase; cancer cells; ligase inhibitors ... See more keywords

Phenolic metabolism in the hornwort Anthoceros agrestis: 4-coumarate CoA ligase and 4-hydroxybenzoate CoA ligase

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recommendations! Published in 2020 at "Plant Cell Reports"

DOI: 10.1007/s00299-020-02552-w

Abstract: 4-Coumarate coenzyme A ligase and 4-hydroxybenzoate coenzyme A ligase from the hornwort Anthoceros agrestis expressed in E. coli were characterized on biochemical and molecular levels and showed interesting substrate specificities. Acyl-activating enzymes are associated with… read more here.

Keywords: coa ligase; anthoceros agrestis; coumaric acid; acid ... See more keywords