PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1716506115
Abstract: Significance Parkinson’s disease (PD) is the second most common neurodegenerative disorder. It is characterized by progressive deterioration of motor function caused by loss of dopamine-producing neurons. Currently, there is no treatment that could stop the… read more here.
Keywords: ligase activity; parkin; ubiquitin ligase; pick1 ... See more keywords
Abstract 2606: Requirement of MDM2 E3 ligase activity for regulating p53 during normal development, cell cycle regulation and genome integrity
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2606
Abstract: p53 tumor suppressor, the most mutated gene in human cancer, is negatively regulated by MDM2 and MDM4 proteins. Two distinct mechanisms of MDM2/MDM4 regulation of p53 include, one, suppression of p53 transactivation activity by direct… read more here.
Keywords: mdm2 ligase; ligase activity; p53; regulation ... See more keywords
Blocking MG53S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury
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DOI: 10.1161/circresaha.122.321055
Abstract: Background: As an integral component of cell membrane repair machinery, MG53 (mitsugumin 53) is important for cardioprotection induced by ischemia preconditioning and postconditioning. However, it also impairs insulin signaling via its E3 ligase activity-mediated ubiquitination-dependent… read more here.
Keywords: mg53; injury; phosphorylation; ligase activity ... See more keywords
Differential requirement for BRCA1-BARD1 E3 ubiquitin ligase activity in DNA damage repair and meiosis in the Caenorhabditis elegans germ line
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DOI: 10.1371/journal.pgen.1010457
Abstract: The tumor suppressor BRCA1-BARD1 complex functions in many cellular processes; of critical importance to its tumor suppressor function is its role in genome integrity. Although RING E3 ubiquitin ligase activity is the only known enzymatic… read more here.
Keywords: dna damage; ligase activity; activity; brca1 bard1 ... See more keywords