Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-52075-1
Abstract: Microtubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-phosphorylation. However, it is often unclear which of these… read more here.
Keywords: phosphorylation; ligase chip; tau; ubiquitin ligase ... See more keywords
Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases
Sign Up to like & getrecommendations! Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0322-6
Abstract: Protein–protein interactions between E3 ubiquitin ligases and protein termini help shape the proteome. These interactions are sensitive to proteolysis, which alters the ensemble of cellular N and C termini. Here we describe a mechanism wherein… read more here.
Keywords: caspase; latent termini; ubiquitin ligase; termini ... See more keywords
Conserved and Unique Roles of Chaperone-Dependent E3 Ubiquitin Ligase CHIP in Plants
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.699756
Abstract: Protein quality control (PQC) is essential for maintaining cellular homeostasis by reducing protein misfolding and aggregation. Major PQC mechanisms include protein refolding assisted by molecular chaperones and the degradation of misfolded and aggregated proteins using… read more here.
Keywords: ubiquitin ligase; chaperone dependent; conserved unique; ligase chip ... See more keywords