CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARF degradation.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00890-0
Abstract: The cystine/glutamate antiporter SLC7A11 (commonly known as xCT) functions to import cystine for glutathione biosynthesis, thereby protecting cells from oxidative stress and ferroptosis, a regulated form of non-apoptotic cell death driven by the accumulation of… read more here.
Keywords: crl2 klhdc3; p14arf; ubiquitin ligase; klhdc3 ... See more keywords
Structure and function of the peroxisomal ubiquitin ligase complex
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20221393
Abstract: Peroxisomes are membrane-bounded organelles that exist in most eukaryotic cells and are involved in the oxidation of fatty acids and the destruction of reactive oxygen species. Depending on the organism, they house additional metabolic reactions… read more here.
Keywords: ubiquitin ligase; structure function; ligase complex; function peroxisomal ... See more keywords
S-Nitrosation of E3 Ubiquitin Ligase Complex Components Regulates Hormonal Signalings in Arabidopsis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.794582
Abstract: E3 ubiquitin ligases mediate the last step of the ubiquitination pathway in the ubiquitin-proteasome system (UPS). By targeting transcriptional regulators for their turnover, E3s play a crucial role in every aspect of plant biology. In… read more here.
Keywords: ligase complex; ubiquitin ligase; nitrosation ubiquitin; nitrosation ... See more keywords
CRL4CRBN E3 Ligase Complex as a Therapeutic Target in Multiple Myeloma
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DOI: 10.3390/cancers14184492
Abstract: Simple Summary Immunomodulatory drugs (IMiDs) are effective in the treatment of multiple myeloma (MM) and other hematological malignancies. Cereblon (CRBN), a target of IMiDs, forms the CRL4 E3 ubiquitin ligase complex (CRL4CRBN) with DDB1, CUL4A… read more here.
Keywords: ligase complex; crbn; myeloma; ligase ... See more keywords
Molecular architecture of the human tRNA ligase complex
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DOI: 10.7554/elife.71656
Abstract: RtcB enzymes are RNA ligases that play essential roles in tRNA splicing, unfolded protein response, and RNA repair. In metazoa, RtcB functions as part of a five-subunit tRNA ligase complex (tRNA-LC) along with Ddx1, Cgi-99,… read more here.
Keywords: trna ligase; ligase complex; molecular architecture; human trna ... See more keywords